On Saturday 19th March 2011, as part of the annual Cambridge Science Festival, LMB scientists are involved in events across Cambridge aimed at promoting science to the general public. Crystal Clear Exhibit Crystal Clear is an exhibit run by the LMB’s Samantha Wynne and Harry Powell, showing various types and sizes of crystalline materials, from large […]
LMB at the Cambridge Science Festival: 19th March.
Heptares Therapeutics helps push GPCR drug discovery forward
“G-protein-coupled receptors are hot drug targets, and plenty of companies want to know what they look like to get an edge on making new drugs. Despite recent advances, getting X-ray crystal structures for GPCRs is still far from easy. Heptares Therapeutics, joins a trio of firms in licensing their structure-determining technology and partnering with large […]
Human antibody approved for treatment of lupus
Systemic lupus erythematosus is a chronic, life-threatening inflammatory autoimmune disease that can cause debilitating fatigue, painful and swollen joints, fever, skin rash, and kidney problems. The disease can also lead to arthritis, kidney failure, heart and lung inflammation, central nervous system abnormalities, inflammation of the blood vessels, and blood disorders. Approximately five million people worldwide […]
A small molecule to correct protein folding defects.
The deposition of misfolded proteins is a central characteristic of many devastating diseases including neurodegenerative diseases such as Alzheimer’s, Parkinson’s, Huntington’s, amyotrophic lateral sclerosis and prion diseases. In principle, improving the cells’ ability to deal with misfolded proteins should reduce the pathology in these diverse neurodegenerative diseases. A study led by Anne Bertolotti has identified […]
Max Perutz: his life and legacy
“LMB scientists take part in a round-table discussion about Max Perutz.” More…
First X-ray crystal structure of dynein motor domain
The first X-ray crystal structure of the motor domain of cytoplasmic dynein, a protein that uses the cellular energy from ATP to walk along microtubule tracks that run throughout the cell, has been solved. Cytoplasmic dynein moves numerous cargos around the cell including proteins and RNAs that set up the cell polarity, membraneous organelles, aggregated […]