LMB scientists showcased their work at the Cambridge Festival with a hands-on activity about the molecular mechanisms of behaviour and science and art collaboration about body clocks.
LMB highlights the scale of molecular biology at the Cambridge Festival
Directional loading mechanism is used by SMC complex to capture and ingest DNA
Led by postdoc Frank Bürmann, Jan Löwe’s group in the LMB’s Structural Studies Division, and Mark Dillingham’s group at the University of Bristol, have identified the mechanism the bacterial SMC complex MukBEF uses to entrap DNA ahead of loop extrusion, and found how this pathway can be inhibited by a bacteriophage protein.
LMB spinout TRIMTECH Therapeutics will develop targeted protein degraders to treat neurodegenerative conditions
Leo James co-founds new UK biotech company together with Will McEwan (UK DRI at Cambridge) leveraging the unique properties of TRIM21, discovered at the LMB.
Writing the LINE-1s: How does LINE-1 remodel human DNA to insert its sequence throughout the genome?
Spearheaded by postdoc George Ghanim, Kelly Nguyen’s group in the LMB’s Structural Studies Division have investigated the molecular mechanisms which allow LINE-1 to propagate throughout the genome via retrotransposition during target-primed reverse transcription.
The moment Max Perutz discovered the structure of haemoglobin
The History Hour by BBC World Service have covered Max Perutz’s Nobel Prize winning work to determine the structure of haemoglobin. Their coverage includes archival interviews with Max himself, plus contributions from Alan Fersht, emeritus scientist in the LMB’s PNAC Division and a contemporary of Max’s. More…
Sortera Bio spins out of the LMB to pioneer new frontiers in biologics discovery
New UK-based biotechnology company launched to realise therapeutic potential of Deep Screening technology developed by Ben Porebski and Philipp Holliger at the LMB.