Time-resolved study of in vitro assembly of truncated tau by the groups of Sjors Scheres and Michel Goedert, from the LMB’s Structural Studies and Neurobiology Divisions, identifies formation of many different disease-specific intermediate amyloid filaments.
Alzheimer’s disease and chronic traumatic encephalopathy tau filament assembly intermediates revealed by cryo-EM
The LMB raises over £1600 for North West Anglia Hospitals’ Charity
The annual LMB Christmas charity raffle, and Craft and Chatter group Christmas sale, has raised over £1600 for The North West Anglia Hospitals’ Charity – Woodlands Centre at Hinchingbrooke Hospital.
Sought FUS, Found TAF—A New Fibril in Frontotemporal Dementia
While filaments of either tau or TDP-43 underlie 90% of frontotemporal dementia cases, the proteopathic culprits behind the remaining 10 percent have eluded researchers. Fused in sarcoma (FUS) often forms inclusions in such cases, hence Benjamin Ryskeldi-Falcon’s group and collaborators expected to find FUS fibrils when they put samples from these patients’ brains through the […]
Celebrating Michel Goedert’s four decades at the LMB
Congratulations to Michel Goedert, Group Leader in the LMB’s Neurobiology Division, who has reached 40 years of service at the LMB.
The band and the rhythm
The latest episode of The EMBO podcast features John O’Neill and Andrew Beale, Group Leader and postdoctoral researcher in the LMB’s Cell Biology Division. They talk about how investigating a mysterious band on a western blot led to a new understanding of the red blood cell’s clockwork mechanism. Read more…
Molecular mechanics of mitotic error correction revealed by cryo-EM
Structure of the outer kinetochore bound to microtubules, determined by David Barford’s group in the Structural Studies Division, reveals how phosphorylation regulates mitotic spindle chromosome attachment errors to ensure DNA is equally segregated into two daughter cells.