Time-lapse quantitative study of developing salivary glands in Drosophila embryos, conducted by Katja Röper’s group, reveals the key control factors behind cells’ behavioural transitions that are essential for correct organ formation.
Early transcriptional patterning of a forming tissue is essential to morphogenesis of a tubular organ
Atomic structure of chromosomal complex responsible for organising DNA determined
Cryo-EM analysis reveals structure of structural maintenance of chromosomes (SMC) complex, and shows for the first time how the protein machinery entraps two DNA helices simultaneously in order to individualise chromosomes.
Scaling-up grid manufacture to solve bottleneck in cryo-EM
Electron cryo-microscopy continues to be a pivotal method for structural biology. Chris Russo’s group, in the LMB’s Structural Studies Division, share an optimisation process to meet increasing demand for cryo-EM grids.
Regulating the disassembly of the eukaryotic DNA replication machinery
Disassembly of the DNA replication machinery, known as the replisome, is the final step of eukaryotic chromosome replication. A collaboration between Joe Yeeles’ group at the LMB and the Deegan lab in Edinburgh shows how replisome disassembly is regulated through ubiquitin ligase activity and stearic hindrance from the DNA itself.
Students and postdocs’ exemplary research recognised by 2021 Perutz and Brenner Prizes
LMB PhD students and postdocs are awarded for breakthroughs in human brain development, DNA replication, yeast GPCRs, dynein motor delivery and ubiquitylation of LPS.
Heart cell clocks help coordinate daily cardiac function
Cell Biology Group Leader, John O’Neill, discusses his group’s recent paper. Their work highlights how heart cells regulate daily function through fluctuations in ion levels. Beginning at 47:00. More…