Wang H., Bienz M., Yan X. X., Xu W.
Structural basis of the interaction between BCL9-Pygo and LDB-SSBP complexes in assembling the Wnt enhanceosome
Nature Communications 14(1):3702DOI: 10.1038/s41467-023-39439-9
PMID: 37349336
PMCID: PMC10287724
Date of Paper: 22/06/2023
Division: Protein & Nucleic Acid ChemistryWang M., Brandt L. T. L., Wang X., Russell H., Mitchell E., Kamimae-Lanning A. N., Brown J. M.., Dingler F. A., Garaycoechea J. I., Isobe T., Kinston S. J., Gu M., Vassiliou G. S., Wilson N. K., Göttgens B., Patel K J.
Genotoxic aldehyde stress prematurely ages hematopoietic stem cells in a p53-driven manner
Molecular Cell 83(14):2417-2433.e7DOI: 10.1016/j.molcel.2023.05.035
PMID: 37348497
PMCID: PMC7614878
Date of Paper: 21/06/2023
Division: Protein & Nucleic Acid ChemistryYatskevich S., Barford D., Muir K. W.
Conserved and divergent mechanisms of inner kinetochore assembly onto centromeric chromatin
Current Opinion in Structural Biology 81:102638DOI: 10.1016/j.sbi.2023.102638
PMID: 37343495
PMCID:
Date of Paper: 20/06/2023
Division: Structural StudiesGaynor K. U., Vaysburd M., Harman M. A. J., Albecka A., Jeffrey P., Beswick P., Papa G., Chen L., Mallery D., McGuinness B., Van Rietschoten K., Stanway S., Brear P., Lulla A, Ciazynska K., Chang V. T., Sharp J., Neary M., Box H., Herriott J., Kijak E., Tatham L., Bentley E. G., Sharma P., Kirby A., Han X., Stewart J. P., Owen A., Briggs J A. G., Hyvönen M., Skynner M. J., James L. C.
Multivalent bicyclic peptides are an effective antiviral modality that can potently inhibit SARS-CoV-2
Nature Communications 14(1):3583DOI: 10.1038/s41467-023-39158-1
PMID: 37328472
PMCID: PMC10275983
Date of Paper: 16/06/2023
Division: Protein & Nucleic Acid ChemistryCazzagon G., Roubinet C., Baum B.
Polarized SCAR and the Arp2/3 complex regulate apical cortical remodeling in asymmetrically dividing neuroblasts
Iscience 26(7):107129DOI: 10.1016/j.isci.2023.107129
PMID: 37434695
PMCID: PMC10331462
Date of Paper: 15/06/2023
Division: Cell BiologyHunter M. R., Cui L., Porebski B. T., Pereira S., Sonzini S., Odunze U., Iyer .P, Engkvist O., Lloyd R. L., Peel S., Sabirsh A., Ross-Thriepland D., Jones A. T., Desai A. S.
Understanding Intracellular Biology to Improve mRNA Delivery by Lipid Nanoparticles
Small Methods 7(9):e2201695DOI: doi.org/10.1002/smtd.202201695
PMID: 37317010
PMCID: PMC7615154
Date of Paper: 14/06/2023
Division: Protein & Nucleic Acid ChemistryPetratou D., Gjikolaj M., Kaulich E., Schafer W., Tavernarakis N.I
A proton-inhibited DEG/ENaC ion channel maintains neuronal ionstasis and promotes neuronal survival under stress
Iscience 26(7):107117DOI: 10.1016/j.isci.2023.107117
PMID: 37416472
PMCID: PMC10320524
Date of Paper: 14/06/2023
Division: NeurobiologyTaisz I., Donà E., Münch D., Bailey S. N., Morris B. J., Meechan K. I., Stevens K. M., Varela-Martínez I., Gkantia M., Schlegel P, Ribeiro C., Jefferis G. S. X. E., Galili D. S.
Generating parallel representations of position and identity in the olfactory system
Cell 186(12): 2556–2573.e22DOI: 10.1016/j.cell.2023.04.038
PMID: 37236194
PMCID: PMC10403364
Date of Paper: 08/06/2023
Division: NeurobiologyOzturk S. F., Liu Z., Sutherland J. D., Sasselov D. D.
Origin of biological homochirality by crystallization of an RNA precursor on a magnetic surface
Science Advances 9(23):eadg8274DOI: 10.1126/sciadv.adg8274
PMID: 37285423
PMCID: PMC10246896
Date of Paper: 07/06/2023
Division: Protein & Nucleic Acid ChemistryBoyle K. B., Ellison C. J., Elliott P. R., Schuschnig M., Grimes K., Dionne M. S., Sasakawa C., Munro S., Martens S., Randow F.
TECPR1 conjugates LC3 to damaged endomembranes upon detection of sphingomyelin exposure
The EMBO Journal 42(17):e113012DOI: 10.15252/embj.2022113012
PMID: 37409490
PMCID: PMC10476172
Date of Paper: 06/06/2023
Division: Protein & Nucleic Acid ChemistryFerreira A. C. F., Szeto A. C. H., Clark P. A., Crisp A., Kozik P., Jolin H. E., McKenzie A. N. J.
Neuroprotective protein ADNP-dependent histone remodeling complex promotes T helper 2 immune cell differentiation
Immunity 56(7):1468-1484.e7DOI: doi.org/10.1016/j.immuni.2023.05.010
PMID: 37285842
PMCID: PMC10501989
Date of Paper: 06/06/2023
Division: Protein & Nucleic Acid ChemistryHöpfler M., Absmeier E., Peak-Chew S. Y., Vartholomaiou E., Passmore L. A.,. Gasic I., Hegde R. S.
Mechanism of ribosome-associated mRNA degradation during tubulin autoregulation
Molecular Cell 83(13):2290-2302.e13DOI: 10.1016/j.molcel.2023.05.020
PMID: 37295431
PMCID: PMC10403363
Date of Paper: 02/06/2023
Division: Cell BiologyRibeiro J, Crossan G.P.
GCNA is a histone binding protein required for spermatogonial stem cell maintenance
Nucleic Acids Research 51(10):4791-4813DOI: 10.1093/nar/gkad168
PMID: 36919611
PMCID: PMC10250205
Date of Paper: 01/06/2023
Division: Protein & Nucleic Acid ChemistryRibeiro J., Crossan G. P.
GCNA is a histone binding protein required for spermatogonial stem cell maintenance
Nucleic Acids Research 51(10):4791-4813DOI: 51(10):4791-4813
PMID: 36919611
PMCID: PMC10250205
Date of Paper: 01/06/2023
Division: Structural StudiesDimou E., Katsinelos T., Meisl G., Tuck B. J., Keeling S., Smith A. E., Hidari E., Lam J. Y. L., Burke M., Lövestam S., Ranasinghe R. T., McEwan W.A., Klenerman D.
Super-resolution imaging unveils the self-replication of tau aggregates upon seeding
Cell Reports 42(7):112725DOI: 10.1016/j.celrep.2023.112725
PMID: 37393617
PMCID: PMC7614924
Date of Paper: 01/06/2023
Division: Structural StudiesAgirre J, Atanasova M, Bagdonas H, Ballard CB, Baslé A, Beilsten-Edmands J, Borges RJ, Brown DG, Burgos-Mármol JJ, Berrisford JM, Bond PS, Caballero I, Catapano L, Chojnowski G, Cook AG, Cowtan KD, Croll TI, Debreczeni JÉ, Devenish NE, Dodson EJ, Drevon TR, Emsley P, Evans G, Evans PR, Fando M, Foadi J, Fuentes-Montero L, Garman EF, Gerstel M, Gildea RJ, Hatti K, Hekkelman ML, Heuser P, Hoh SW, Hough MA, Jenkins HT, Jiménez E, Joosten RP, Keegan RM, Keep N, Krissinel EB, Kolenko P, Kovalevskiy O, Lamzin VS, Lawson DM, Lebedev AA, Leslie AGW, Lohkamp B, Long F, Malý M, McCoy AJ, McNicholas SJ, Medina A, Millán C, Murray JW, Murshudov GN, Nicholls RA, Noble MEM, Oeffner R, Pannu NS, Parkhurst JM, Pearce N, Pereira J, Perrakis A, Powell HR, Read RJ, Rigden DJ, Rochira W, Sammito M, Sánchez Rodríguez F, Sheldrick GM, Shelley KL, Simkovic F, Simpkin AJ, Skubak P, Sobolev E, Steiner RA, Stevenson K, Tews I, Thomas JMH, Thorn A, Valls JT, Uski V, Usón I, Vagin A, Velankar S, Vollmar M, Walden H, Waterman D, Wilson KS, Winn MD, Winter G, Wojdyr M, Yamashita K.
The CCP4 suite: integrative software for macromolecular crystallography
Acta crystallographica. Section D, Structural Biology 79(Pt 6):449-461DOI: 10.1107/s2059798323003595
PMID: 37259835
PMCID: PMC10233625
Date of Paper: 30/05/2023
Division: Structural StudiesBravo-Plaza I., Tagua V. G., Arst H. N. Jr, Alonso A., Pinar M., Monterroso B., Galindo A., Peñalva M. A.
The Uso1 globular head interacts with SNAREs to maintain viability even in the absence of the coiled-coil domain
Elife 12:e85079DOI: 10.7554/elife.85079
PMID: 37249218
PMCID: PMC10275640
Date of Paper: 30/05/2023
Division: Cell BiologyAgirre J, Atanasova M, Bagdonas H, Ballard CB, Baslé A, Beilsten-Edmands J, Borges RJ, Brown DG, Burgos-Mármol JJ, Berrisford JM, Bond PS, Caballero I, Catapano L, Chojnowski G, Cook AG, Cowtan KD, Croll TI, Debreczeni JÉ, Devenish NE, Dodson EJ, Drevon TR, Emsley P, Evans G, Evans PR, Fando M, Foadi J, Fuentes-Montero L, Garman EF, Gerstel M, Gildea RJ, Hatti K, Hekkelman ML, Heuser P, Hoh SW, Hough MA, Jenkins HT, Jiménez E, Joosten RP, Keegan RM, Keep N, Krissinel EB, Kolenko P, Kovalevskiy O, Lamzin VS, Lawson DM, Lebedev AA, Leslie AGW, Lohkamp B, Long F, Malý M, McCoy AJ, McNicholas SJ, Medina A, Millán C, Murray JW, Murshudov GN, Nicholls RA, Noble MEM, Oeffner R, Pannu NS, Parkhurst JM, Pearce N, Pereira J, Perrakis A, Powell HR, Read RJ, Rigden DJ, Rochira W, Sammito M, Sánchez Rodríguez F, Sheldrick GM, Shelley KL, Simkovic F, Simpkin AJ, Skubak P, Sobolev E, Steiner RA, Stevenson K, Tews I, Thomas JMH, Thorn A, Valls JT, Uski V, Usón I, Vagin A, Velankar S, Vollmar M, Walden H, Waterman D, Wilson KS, Winn MD, Winter G, Wojdyr M, Yamashita K.
The CCP4 suite: integrative software for macromolecular crystallography
Acta crystallographica. Section D, Structural Biology 79(Pt 6):449-461DOI: 10.1107/s2059798323003595
PMID: 37259835
PMCID: PMC10233625
Date of Paper: 30/05/2023
Division: Structural StudiesHastings M. H., Brancaccio M., Gonzalez-Aponte M. F., Herzog E. D.
Circadian Rhythms and Astrocytes: The Good, the Bad, and the Ugly
Annual Review of Neuroscience 46:123-143DOI: 10.1146/annurev-neuro-100322-112249
PMID: 36854316
PMCID: PMC10381027
Date of Paper: 28/05/2023
Division: NeurobiologyHakanpää L., Abouelezz A., Lenaerts A. S., Culfa S., Algie M., Bärlund J., Katajisto P., McMahon H., Almeida-Souza L.
Reticular adhesions are assembled at flat clathrin lattices and opposed by active integrin α5β1
The Journal of Cell Biology 222(8):e202303107DOI: 10.1083/jcb.202303107
PMID: 37233325
PMCID: PMC10225744
Date of Paper: 26/05/2023
Division: NeurobiologyHakanpää L., Abouelezz A., Lenaerts A. S., Culfa S, Algie M., Bärlund J., Katajisto P., McMahon H., Almeida-Souza L.
Reticular adhesions are assembled at flat clathrin lattices and opposed by active integrin α5β1
The Journal of Cell Biology 222(8):e202303107DOI: 0.1083/jcb.202303107
PMID: 37233325
PMCID: PMC10225744
Date of Paper: 26/05/2023
Division: NeurobiologyZhang D., Lape R., Shaikh S. A., Kohegyi B. K., Watson J. F., Cais O., Nakagawa T., Greger I. H
Modulatory mechanisms of TARP γ8-selective AMPA receptor therapeutics
Nature Communication 14(1):1659DOI: 10.1038/s41467-023-37259-5
PMID: 36966141
PMCID: PMC10039940
Date of Paper: 25/05/2023
Division: NeurobiologyLemus L., Hegde R. S, Goder V.
New frontiers in quality control: the case of GPI-anchored proteins
Nature reviews. Molecular Cell BiologyDOI: 10.1038/s41580-023-00616-9
PMID: 37231113
PMCID:
Date of Paper: 25/05/2023
Division: Cell BiologyGong GQ, Bilanges B, Allsop B, Masson GR, Roberton V, Askwith T, Oxenford S, Madsen RR, Conduit SE, Bellini D, Fitzek M, Collier M, Najam O, He Z, Wahab B, McLaughlin SH, Chan AWE, Feierberg I, Madin A, Morelli D, Bhamra A, Vinciauskaite V, Anderson KE, Surinova S, Pinotsis N, Lopez-Guadamillas E, Wilcox M, Hooper A, Patel C, Whitehead MA, Bunney TD, Stephens LR, Hawkins PT, Katan M, Yellon DM, Davidson SM, Smith DM, Phillips JB, Angell R, Williams RL, Vanhaesebroeck B
A small-molecule PI3Kα activator for cardioprotection and neuroregeneration.
Nature 618(7963):159-168DOI: 10.1038/s41586-023-05972-2
PMID: 37225977
PMCID: PMC7614683
Date of Paper: 24/05/2023
Division: Protein & Nucleic Acid ChemistryGong GQ, Bilanges B, Allsop B, Masson GR, Roberton V, Askwith T, Oxenford S, Madsen RR, Conduit SE, Bellini D, Fitzek M, Collier M, Najam O, He Z, Wahab B, McLaughlin SH, Chan AWE, Feierberg I, Madin A, Morelli D, Bhamra A, Vinciauskaite V, Anderson KE, Surinova S, Pinotsis N, Lopez-Guadamillas E, Wilcox M, Hooper A, Patel C, Whitehead MA, Bunney TD, Stephens LR, Hawkins PT, Katan M, Yellon DM, Davidson SM, Smith DM, Phillips JB, Angell R, Williams RL, Vanhaesebroeck B.
A small-molecule PI3Kα activator for cardioprotection and neuroregeneration
Nature 18(7963):159-168DOI: 10.1038/s41586-023-05972-2
PMID: 37225977
PMCID: PMC7614683
Date of Paper: 24/05/2023
Division: Protein & Nucleic Acid Chemistry