Scientists in Lori Passmore’s group in the LMB’s Structural Studies Division have revealed new mechanistic insights into the link between translation and mRNA decay. In collaboration with Jeff Coller’s group at Case Western Reserve University, USA, and Brenton Graveley’s group at the University of Connecticut, USA, the scientists’ findings have implications for understanding regulation of […]
Insight on Research
Uncovering the structure of the serotonin receptor
Scientists in Chris Tate’s group in the LMB’s Structural Studies Division have used electron cryo-microscopy to determine the structure of the serotonin receptor coupled to the heterotrimeric G protein Go, providing insights into how receptors bind specific G proteins. Communication between cells throughout our bodies is vital for our health. Cells release signals, such as […]
Controlling actin polymerisation in clathrin mediated endocytosis
Work from Harvey McMahon’s group in the LMB’s Neurobiology Division has uncovered how a protein, FCHSD2, controls actin polymerisation during endocytosis. Importantly the scientists discovered that FCHSD2 does its job from the area surrounding the site of endocytosis – making it the first description of an endocytic protein which localises to the flat region around […]
Parkin activation and early-onset Parkinson’s disease: the last piece of the puzzle
Researchers at the LMB have solved the elusive 3D structure of activated Parkin, an enzyme implicated in early-onset Parkinson’s disease. Led by David Komander’s group in the LMB’s PNAC Division, in collaboration with the LMB’s Biological Mass Spectrometry facility, this new work reveals insights into previously unstudied parts of this important protein and helps explain […]
How does the replisome respond to DNA damage?
Work by Joe Yeeles’ group in the LMB’s PNAC Division has for the first time revealed the earliest responses when the eukaryotic DNA replication machinery, the replisome, collides with DNA damage. Every time a cell divides, its DNA must be replicated so that each daughter cell inherits a complete copy of the genome. Since DNA […]
HIV exploits a native cellular molecule to increase the stability of its capsid
Scientists in Leo James’ group in the LMB’s PNAC Division, in collaboration with Till Böcking’s group at the University of New South Wales, Australia and Adolfo Saiardi’s group at the MRC Laboratory for Molecular Cell Biology, have uncovered how the HIV virus stabilises its capsid by binding to an abundant cellular polyanion, IP6. IP6 increases HIV […]