David Barford’s group, in the LMB’s Structural Studies Division, in collaboration with John Kilmartin in the LMB’s Cell Biology Division, have used electron cryo-tomography and sub-tomogram averaging to determine the structure of native γTuRC capping microtubules from extracted Spindle Pole Bodies.
Insight on Research
New 3D embryonic stem cell culture system sheds light on gastrulation mechanism
Marta Shahbazi’s group in the LMB’s Cell Biology Division has developed a three-dimensional embryonic stem cell culture system to study the molecular motivations behind basal delamination where cells change shape and move from their tissue of origin.
A genome-wide resource for dissecting transport within cells
Chun Hao Wong and Simon Bullock, from the LMB’s Cell Biology Division, together with Douglas Ross-Thriepland and colleagues at AstraZeneca, have systematically disrupted every gene in cultured human cells to reveal a large number of new factors required for organisation of cells by the microtubule motor dynein.
New insights into genetic mechanisms involved in kidney development
John-Poul Ng-Blichfeldt and Katja Röper, in the LMB’s Cell Biology Division, have collaborated with Julie Williams from AstraZeneca, to use renal organoids to investigate the human mesenchymal-to-epithelial transition, crucial to the morphogenesis of kidneys.
Phosphatase study solves substrate recruitment puzzle
Anne Bertolotti’s group in the LMB Neurobiology Division have revealed the substrate recruitment mechanism of major phosphatase non-catalytic subunit, PPP1R15B, by using full-length eIF2 and a combination of approaches.
Alzheimer’s disease and chronic traumatic encephalopathy tau filament assembly intermediates revealed by cryo-EM
Time-resolved study of in vitro assembly of truncated tau by the groups of Sjors Scheres and Michel Goedert, from the LMB’s Structural Studies and Neurobiology Divisions, identifies formation of many different disease-specific intermediate amyloid filaments.