The discovery of TAF15 amyloid filaments in patients with frontotemporal lobar degeneration by the group of Benjamin Ryskeldi-Falcon in the LMB’s Neurobiology Division establishes this protein as a diagnostic and therapeutic target for this neurodegenerative disorder.
Insight on Research
Low energy cryo-EM to widen accessibility for fast and accurate structure determination
A collaborative team lead by Chris Russo’s group in the LMB’s Structural Studies Division has developed a new electron cryo-microscope, capable of solving atomic structures at a fraction of the energy and cost of existing models.
First map of wireless communication in the nervous system
The entire wireless neuropeptide signalling network of a whole animal, the nematode worm C. elegans, has been mapped for the first time by William Schafer’s group in the LMB’s Neurobiology Division and collaborators.
New mechanism found that maintains intracellular water balance
A collaboration between the groups of Emmanuel Derivery, and John O’Neill in the LMB’s Cell Biology Division, and Rachel Edgar’s group at Imperial College London, have discovered a rapid mechanism by which cells ensure that an optimal balance of water is available for biochemical reactions and protein structure and function.
New deep screening technique enables rapid discovery of high-affinity antibodies to clinically relevant drug targets
Philipp Holliger and Ben Porebski in the LMB’s PNAC Division, in collaboration with AstraZeneca, have developed a new ultra-high-throughput method that shows promise to accelerate antibody discovery for a wide range of targets.
New method to untangle the contribution of signalling pathways involved in asymmetric cell division
Emmanuel Derivery’s group, in the LMB’s Cell Biology Division, has developed a method to directly untangle the contribution of any signalling pathway involved in asymmetric cell division.