Led by Mayuri Gogoi, Andrew McKenzie’s group in the LMB’s PNAC Division have determined that the cytokine LIF production by type-2 innate lymphoid cells dictates the movement of immune cells from the site of lung infection or chronic allergic reaction, thereby regulating tissue localised versus systemic immunity.
Insight on Research
Combining single molecule-imaging and cryo-EM resolves DNA repair mystery
Lori Passmore’s group in the LMB’s Structural Studies Division have identified the molecular mechanism by which the FANCD2-FANCI protein complex, which acts as a travelling DNA clamp, is able to identify sites of DNA strand damage and mark them for repair.
Motion detector in the brain translates visual information into movement
Marco Tripodi’s group, in the LMB’s Neurobiology Division, reveals how visual information is progressively channelled to motor neurons.
Transcription factor Mef2d is crucial to the function of type-2 innate lymphoid cells during allergic responses
Andrew McKenzie’s group, in the LMB’s PNAC Division, have applied a new screening system and synthetic Boolean logic gate circuits to offer unprecedented insights into the molecular regulation of type-2 innate lymphoid cells, a key contributor to allergic responses.
In-cell structure elucidation reveals a functional significance of microbial S-layers in critical global geochemical cycles
Tanmay Bharat’s group, in the LMB’s Structural Studies Division, reveals the surface layer structure of the archaeon Nitrosopumilus maritimus, crucial to the global nitrogen cycle.
First map of the neurotransmitters used in the fruit fly brain
Greg Jefferis’ group in the LMB’s Neurobiology Division, in collaboration with scientists at the Janelia Research Campus, have predicted the sign of each synapsis in the fruit fly brain.