“Parkinson’s disease might have much in common with Alzheimer’s disease, prion diseases and other protein-aggregation disorders… Like many other researchers, Goedert [LMB] now suspects that α-synuclein aggregation is the primary event in Parkinson’s disease — perhaps triggered by toxins or other environmental factors inside the intestines and sinuses. Most of the pathology in the brain […]
Secrets of the shaking palsy
Body clock drugs could ease psychiatric disorders and jet lag
A collaborative research group based at the LMB and the University of Manchester have successfully used a drug to reset and restart the natural 24-hour body clock of mice in the lab. The ability to do this in a mammal opens up the possibility of dealing with a range of human difficulties including some psychiatric […]
Body clock drugs could ease psychiatric disorders and jet lag
“Researchers have successfully used a drug to reset and restart the natural 24 hour body clock of mice in the lab. The ability to do this in a mammal opens up the possibility of dealing with a range of human difficulties including some psychiatric disorders, jet lag and the health impacts of shift work. This […]
Body clock pills ‘could cure jet lag and manic depression’
“A team of British and American scientists have found a drug which can slow down, kick start and reset the body clocks of mice. It does this by altering a key enzyme which controls the process, called casein kinase 1… He [Prof Loudon] and Dr Mick Hastings of the Medical Research Council Laboratory of Molecular […]
Brad Amos elected Honorary Fellow of the Royal Microscopical Society
Dr Brad Amos, group leader in LMB’s Structural Studies Division, has been elected as an Honorary Fellow of the Royal Microscopical Society (RMS). The Society aims to advance science and support wider understanding of science and microscopy. Honorary Fellowship is the highest honour that the Society can bestow on an individual, and this award recognises […]
Receptive receptors
“One route to developing new drugs is to look at targeting the hundreds of G-protein-coupled receptors that are not currently exploited clinically… Richard Henderson of the Medical Research Council (MRC) Laboratory of Molecular Biology in Cambridge, UK, an experienced researcher in membrane protein structure, describes them as ‘signalling molecules that control the whole of physiology.” […]