Sean Munro’s group in the LMB’s Cell Biology Division, and Matthew Freeman at the Dunn School of Pathology, University of Oxford, have built the ‘Unknome’ database, which ranks human genes based on how much is known about them. They found that surprisingly little is known about an estimated fifth of the human genome, and that […]
The ‘Unknome’ genes which make up a fifth of the human genome
Repurposed DNA repair factors prevent expansions of ‘parasitic’ genomic retrotransposons
Nazareno Bona and Gerry Crossan, in the LMB’s PNAC Division, present a mechanistic explanation of how Fanconi anaemia factors act in a common pathway to restrict LINE-1 retrotransposition.
Muriel Wigby 1932 – 2023
The LMB has sadly learned that Muriel Wigby, who worked as a technician with Sydney Brenner for many years, has died aged 91.
LMB staff share their creative side at the Arts and Crafts Show
Nearly 20 LMB staff have shown off their creative talents at the annual LMB Arts and Crafts Show. The exhibition, which has run for over 10 years, featured work across a wide range of different media.
A database to identify important genes of unknown function for analysis
Sean Munro’s group in the LMB’s Cell Biology Division have investigated the potential biological significance of conserved genes of unknown function by developing an Unknome database to systematically analyse their identification and characterisation.
TDP-43 forms amyloid filaments with distinct folds in different neurodegenerative conditions
Cryo-EM structures from the most common type of frontotemporal lobar degeneration, determined by Benjamin Ryskeldi-Falcon’s group in the LMB’s Neurobiology Division, reveals that TDP-43 forms amyloid filaments with distinct folds in different neurodegenerative conditions.