Ramanujan Hegde talks about protein localization inside cells and quality control of this process. More…
Protein localization inside cells
Mechanism for cleaning up leftover proteins
The cells in our body contain numerous molecular machines that carry out nearly all biological processes essential for life. These machines are built from proteins that are often assembled into complex structures. For example ribosomes contain 80 distinct proteins on a scaffold of four different RNAs. The assembly of such structures from so many parts […]
Uncovering the action of a selective holophosphatase inhibitor
Proteins can be reversibly phosphorylated – phosphate groups are added to proteins by the action of kinase enzymes and can be removed by phosphatases. This controls a huge variety of cellular processes and targeting phosphorylation thus offers a board range of therapeutic opportunities. Indeed, kinases have received much attention in pharmaceutical research, yet phosphatases have […]
Reprogramming gene expression with small molecules
When cells divide, they must accurately copy their genetic material (DNA) and also ensure that their pattern of gene expression is maintained – genes that were ‘on’ before the cell divides need to remain on in the daughter cell, and genes that were ‘off’ need to remain off. These patterns of gene expression are determined […]
LMB alumni return to share their career experiences
The LMB and Cambridge AWiSE recently held their 11th annual “What Next For Your Career in Science?” event in the LMB’s Max Perutz Lecture Theatre. The three speakers, Monika Papworth, Elizabeth Fairley and Sarah Cumbers, were all LMB alumni, who since leaving the LMB have gone on to be successful in diverse areas. All of […]
Artistic flair on show at the LMB
LMB staff shared their artistic flair during the annual LMB Art Show, with exhibits including hand-made jewellery, paintings, photographs, cross stitch and crafts on display in the LMB atrium for all to see and enjoy for two weeks in July. A wide range of creativity was on show from the 22 exhibitors who took part […]