New research shows that acetaldehyde, the breakdown product generated when the body removes alcohol, causes irreversible damage to the DNA of stem cells in the body’s ‘blood cell factory’ – the bone marrow. The research, published in Nature, was carried out by a team of scientists led by KJ Patel in the LMB’s PNAC Division. […]
Insight on Research
Genetic code engineering in Drosophila melanogaster
In the past few years, the ability to incorporate unnatural amino acids into proteins has begun to have a direct impact on the ability of scientists to study biological processes that are difficult or impossible to address by more classical methods. New research, led by members of Jason Chin’s group in the LMB’s PNAC Division, […]
New Insight on General Mechanism Behind Gene Expression
New research, resulting from a collaboration between two groups, led by Sarah Teichmann and Madan Babu, in the LMB’s Structural Studies Division, advances our understanding of the interplay between the two most abundant classes of DNA binding proteins that are responsible for regulating physiological diversity in organisms. Although the two types of proteins that coordinate […]
Research shows the power of exploiting publicly available data to reveal new principles in biology
A comprehensive investigation of several large-scale datasets, led by M. Madan Babu’s group in the LMB’s Structural Studies Division, provides new insights into tissue-specific splicing – the mechanism responsible for increasing the functional diversity of proteins and for attaining tissue identity during development. The research, published in Molecular Cell, focuses on the issue of how […]
Short evolutionary path from DNA to RNA polymerases revealed
New research, led by Philipp Holliger’s group in the LMB’s PNAC Division, has shed new light on the mechanism by which DNA polymerases – the enzymes responsible for replicating genomes in all animals, fungi and bacteria – are able to ensure faithful DNA replication while actively excluding damaged and/or non-cognate nucleotides from the genome. As […]
Development of new genetic polymers
A group of researchers, led by Philipp Holliger in the LMB’s PNAC Division, have created the first synthetic molecules that, alongside the natural molecules DNA and RNA, are capable of storing and replicating genetic information. Vitor Pinheiro and colleagues from Philipp’s group used sophisticated protein engineering techniques to adapt enzymes, that in nature synthesise and […]