Protein phosphorylation is a key post-translational modification that is used to regulate many essential cell processes. A phosphate group is added to a specific site in a protein to switch that protein on or off, depending on its role. It has been challenging to understand the function of protein phosphorylation because it is difficult to […]
Encoding phosphoserine allows production of phosphorylated proteins
ISCB Senior Scientist Award for Cyrus Chothia
A look at the career of LMB’s Cyrus Chothia and his work on the structures and functions of proteins, following announcement of his ISCB Senior scientist award. More…
New Approach To Control Enzyme Function In Cells
A new technique, devised by Jason Chin’s group, could make it easier to target and inhibit specific enzymes and other proteins in cells and to turn that regulation on and off at will with light. Bioorthogonal ligand tethering, or BOLT, has been used to create an inhibitor that can regulate the activity of a target […]
Simon Bullock and Philipp Holliger elected to EMBO membership
Two LMB group leaders, Simon Bullock from the Cell Biology Division and Philipp Holliger from the PNAC Division, have been named in the European Molecular Biology Organisation (EMBO) list of new members announced on the 20th of May. EMBO elects new members annually on the basis of scientific excellence and outstanding research contributions. The organisation promotes […]
BOLT, a fast and selective way to regulate protein function in live cells
Small molecules are often used to regulate the functions of proteins and provide many drugs and tools for understanding biological pathways. However, selectively controlling a specific target protein within living cells is a major challenge. Jason Chin’s group from the LMB’s PNAC Division have created a new technique called BOLT that can selectively regulate specific […]
A new genetic switch uncovered in the long genes expressed in our brain
Jernej Ule, former LMB group leader, and Vincent Plagnol from UCL have discovered a new mechanism for ‘splicing-based’ gene regulation, with possible implications for brain-related disorders. Jernej began this research when he was in the LMB’s Structural Studies Division. More…