The MRC Laboratory of Molecular Biology (LMB) is a research institute dedicated to the understanding of important biological processes at the levels of atoms, molecules, cells and organisms. In doing so, we provide knowledge needed to solve key problems in human health.
Our scientists tackle fundamental, often difficult and long-term research problems. The LMB has made revolutionary contributions to science, such as pioneering X-ray crystallography and electron cryo-microscopy (cryo-EM) to determine protein structures, the sequencing of DNA and the development of monoclonal antibodies. Twelve Nobel Prizes have been awarded for work carried out by LMB scientists.
The LMB also promotes the application and exploitation of our research findings, both by collaboration with existing companies and the founding of new ones, helping to advance medical research and the translation and application of knowledge.
The LMB provides an unsurpassed environment for both young and established researchers, with state-of-the-art facilities and a unique scientific culture. The LMB has always been very diverse, with a truly international outlook. We currently employ men and women from over 50 countries, and LMB alumni work in research organisations across the world.
Colorectal cancer is one of the most common cancers in the UK. Virtually all colorectal cancers are initiated by hyperactive signalling through the Wnt/β-catenin pathway. This can occur due to activating mutations in the protein β-catenin or inactivation of Adenomatous Polyposis Coli (APC),
Dyneins are a family of motor proteins that run along the microtubule tracks that make up the cytoskeleton. They drive beating of cilia/flagellar and transport of cargos, contributing to processes such as clearing mucus, allowing sperm to swim, positioning organelles and clearing up misfolded proteins.
- LMB YouTube channel relaunch
Did you know that the LMB has a YouTube channel where you can find out […]
- Jason Chin awarded the 2019 Sackler Prize
Jason Chin, joint Head of the LMB’s PNAC Division, has been awarded the 2019 Raymond […]
- Tips for overcoming research challenges – Ana Casañal
- Rob Kay and Peggy Paschke have a new video on JoVE that presents their methods for transfection of Dictyostelium cells
- Bcl9 and Pygo synergise downstream of Apc to effect intestinal neoplasia in FAP mouse models.
Mieszczanek, J., van Tienen, LM., Ibrahim, AEK., Winton, DJ., Bienz, M.
Nat Commun 10(1): 724. (13th February 2019)
- Architectural principles for Hfq/Crc-mediated regulation of gene expression.
Pei, XY., Dendooven, T., Sonnleitner, E., Chen, S., Blasi, U., Luisi, BF.
Elife 8 [Epub ahead of print]. (13th February 2019)
- CFTR Protects against Mycobacterium abscessus Infection by Fine-Tuning Host Oxidative Defenses.
Bernut, A., et al.
Cell Rep 26(7): 1828-1840.e4. (12th February 2019)
- Crystal structure of plant vacuolar iron transporter VIT1.
Kato, T., et al.
Nat Plants [Epub ahead of print]. (11th February 2019)
- Innate Lymphoid Cells of the Lung.
Barlow, JL., McKenzie, ANJ.
Annu. Rev. Physiol. 81: 429-452. (10th February 2019)
- A conserved molecular switch in Class F receptors regulates receptor activation and pathway selection.
Wright, SC., et al.
Nat Commun 10(1): 667. (8th February 2019)
- Author Correction: GABA receptor signalling mechanisms revealed by structural pharmacology.
Masiulis, S., et al.
Nature [Epub ahead of print]. (7th February 2019)
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