The MRC Laboratory of Molecular Biology (LMB) is a research institute dedicated to the understanding of important biological processes at the levels of atoms, molecules, cells and organisms. In doing so, we provide knowledge needed to solve key problems in human health.
Our scientists tackle fundamental, often difficult and long-term research problems. The LMB has made revolutionary contributions to science, such as pioneering X-ray crystallography and electron cryo-microscopy (cryo-EM) to determine protein structures, the sequencing of DNA and the development of monoclonal antibodies. Twelve Nobel Prizes have been awarded for work carried out by LMB scientists.
The LMB also promotes the application and exploitation of our research findings, both by collaboration with existing companies and the founding of new ones, helping to advance medical research and the translation and application of knowledge.
The LMB provides an unsurpassed environment for both young and established researchers, with state-of-the-art facilities and a unique scientific culture. The LMB has always been very diverse, with a truly international outlook. We currently employ men and women from over 50 countries, and LMB alumni work in research organisations across the world.
Researchers in Jason Chin’s group in the LMB’s PNAC Division have for the first time engineered and optimised a ‘stapled’ ribosome that can act as a cell-based factory for synthetic protein polymer synthesis. We are familiar with polymers in everyday life, from…
Circadian rhythms dominate our lives through our daily cycle of sleep and wakefulness. These rhythms are controlled by a master clock in the brain: the suprachiasmatic nucleus (SCN). Studying neuronal cell biology and how the SCN drives behaviour in humans and all…
- Songs fill the atrium at the LMB musical evening
After the success of the inaugural event last year, the LMB held its second musical […]
- Max Perutz Lecture to be given by Eric Gouaux
Eric Gouaux will give the 2018 Max Perutz Lecture on Thursday 29th November 2018 at 4pm […]
- Stable research funding drives Britain’s ‘Nobel factory’ – The Financial Times looks into the LMB’s formula for scientific success
- For difficult-to-model brain diseases, brain organoids come to the rescue
- Hexameric assembly of the AAA+ protein McrB is necessary for GTPase activity.
Nirwan, N., et al.
Nucleic Acids Res. [Epub ahead of print]. (6th December 2018)
- SUMOylation of Periplakin is critical for efficient re-organization of Keratin filament network.
Gujrati, M., Mittal, R., Ekal, L., Mishra, RK.
Mol. Biol. Cell : mbcE18040244 [Epub ahead of print]. (5th December 2018)
- Controlling orthogonal ribosome subunit interactions enables evolution of new function.
Schmied, WH., Tnimov, Z., Uttamapinant, C., Rae, CD., Fried, SD., Chin, JW.
Nature [Epub ahead of print]. (5th December 2018)
- Beta-sheet assembly of Tau and neurodegeneration in Drosophila melanogaster.
Passarella, D., Goedert, M.
Neurobiol. Aging 72: 98-105. (3rd December 2018)
- Quantitative Imaging and the Effect of Tissue Topology on Morphogenesis.
Dev. Cell 47(5): 537-538. (3rd December 2018)
- Publisher Correction: Acute and rapid degradation of endogenous proteins by Trim-Away.
Clift, D., So, C., McEwan, WA., James, LC., Schuh, M.
Nat Protoc [Epub ahead of print]. (30th November 2018)
- Lentiviral transduction of mammalian cells for fast, scalable and high-level production of soluble and membrane proteins.
Elegheert, J., et al.
Nat Protoc 13(12): 2991-3017. (30th November 2018)
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