About Us
The MRC Laboratory of Molecular Biology (LMB) is a research institute dedicated to the understanding of important biological processes at the levels of atoms, molecules, cells and organisms. In doing so, we provide knowledge needed to solve key problems in human health.
Our scientists tackle fundamental, often difficult and long-term research problems. The LMB has made revolutionary contributions to science, such as pioneering X-ray crystallography and electron cryo-microscopy (cryo-EM) to determine protein structures, the sequencing of DNA and the development of monoclonal antibodies. Twelve Nobel Prizes have been awarded for work carried out by LMB scientists.
The LMB also promotes the application and exploitation of our research findings, both by collaboration with existing companies and the founding of new ones, helping to advance medical research and the translation and application of knowledge.
The LMB provides an unsurpassed environment for both young and established researchers, with state-of-the-art facilities and a unique scientific culture. The LMB has always been very diverse, with a truly international outlook. We currently employ men and women from over 50 countries, and LMB alumni work in research organisations across the world.
Insight on Research
Newly identified quality control mechanism of RNA Polymerase II transcription
Ana Tufegdžić Vidaković’s group, in the LMB’s PNAC Division, have worked with Scott Berry’s group, at the University of New South Wales, to identify the mechanism cells use to regulate gene expression via control of quality and quantity of Pol II molecules.
Discovery of a factor that accelerates protein deliveries to the endoplasmic reticulum
Huping Wang and Manu Hegde, in the LMB's Cell Biology Division, have found a factor that helps nascent secretory and membrane proteins quickly access the protein translocation machinery when they arrive at the endoplasmic reticulum.
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Latest News
- Starter for Ten: Oscar Despard recounts his University Challenge experience
Oscar Despard, who recently joined the LMB’s Cell Biology Division to complete a Ph.D. with Juliette Fedry, reflects on captaining a University Challenge team. […]
- Anna Edmondson: gaining confidence and science communication skills through FameLab and public engagement
Anna Edmondson shares her experience in Public Engagement, reflecting on the benefits of connecting with a non-specialist audience, and encourages others to explore the various engagement opportunities the LMB offers. […]
Latest Publications
- NAC regulates metabolism and cell fate in intestinal stem cells.
Ramalho, S., et al.
Sci Adv 11(2): eadn9750. (10th January 2025) - The Psu protein of phage satellite P4 inhibits transcription termination factor ρ by forced hyper-oligomerization.
Gjorgjevikj, D., et al.
Nat Commun 16(1): 550. (9th January 2025) - Substrate stiffness-dependent activation of Hippo pathway in cancer associated fibroblasts.
Rubí-Sans, G., Nyga, A., Mateos-Timoneda, MA., Engel, E.
Biomater Adv 166: 214061. (9th January 2025) - Indirect Formation of Peptide Bonds as a Prelude to Ribosomal Transpeptidation.
Dale, HJA., Sutherland, JD.
J Am Chem Soc 147(1): 305-317. (8th January 2025) - Highly Efficient Transpeptidase-Catalyzed Isopeptide Ligation.
de Veer, SJ., Craik, DJ., Rehm, FBH.
J Am Chem Soc 147(1): 557-565. (8th January 2025) - A physical model for M1-mediated influenza A virus assembly.
Peukes, J., Dmitrieff, S., Nédélec, FJ., Briggs, JAG.
Biophys J 124(1): 134-144. (7th January 2025) - InterPro: the protein sequence classification resource in 2025.
Blum, M., et al.
Nucleic Acids Res 53(D1): D444-D456. (6th January 2025)
See more Publications