About Us
The MRC Laboratory of Molecular Biology (LMB) is a research institute dedicated to the understanding of important biological processes at the levels of atoms, molecules, cells and organisms. In doing so, we provide knowledge needed to solve key problems in human health.
Our scientists tackle fundamental, often difficult and long-term research problems. The LMB has made revolutionary contributions to science, such as pioneering X-ray crystallography and electron cryo-microscopy (cryo-EM) to determine protein structures, the sequencing of DNA and the development of monoclonal antibodies. Twelve Nobel Prizes have been awarded for work carried out by LMB scientists.
The LMB also promotes the application and exploitation of our research findings, both by collaboration with existing companies and the founding of new ones, helping to advance medical research and the translation and application of knowledge.
The LMB provides an unsurpassed environment for both young and established researchers, with state-of-the-art facilities and a unique scientific culture. The LMB has always been very diverse, with a truly international outlook. We currently employ men and women from over 50 countries, and LMB alumni work in research organisations across the world.
Insight on Research
Transcription factor Mef2d is crucial to the function of type-2 innate lymphoid cells during allergic responses
![](https://www2.mrc-lmb.cam.ac.uk/wordpress/wp-content/uploads/McKenzie_Szeto_Science_Mef2d_06.2024_sq-150x150.jpg)
Andrew McKenzie’s group, in the LMB’s PNAC Division, have applied a new screening system and synthetic Boolean logic gate circuits to offer unprecedented insights into the molecular regulation of type-2 innate lymphoid cells, a key contributor to allergic responses.
In-cell structure elucidation reveals a functional significance of microbial S-layers in critical global geochemical cycles
![](https://www2.mrc-lmb.cam.ac.uk/wordpress/wp-content/uploads/Bharat_Tanmay_Nature_IoR_square-150x150.jpg)
Tanmay Bharat’s group, in the LMB’s Structural Studies Division, reveals the surface layer structure of the archaeon Nitrosopumilus maritimus, crucial to the global nitrogen cycle.
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Latest News
Kiarash Jamali and David Posner receive Ph.D. Student Awards from Cambridge Society for the Application of Research
Congratulations to Ph.D. students Kiarash Jamali and David Posner who have received Ph.D. Student Awards from CSAR. […]
Lalita Ramakrishnan awarded 2024 Robert Koch Prize
Lalita Ramakrishnan, Group Leader in the LMB’s Cell Biology Division and the Molecular Immunity Unit, receives the award in recognition of her pioneering research into tuberculosis. […]
Latest Publications
- Tuning synaptic strength by regulation of AMPA glutamate receptor localization.
Stockwell, I., Watson, JF., Greger, IH.
Bioessays 46(7): e2400006. (1st July 2024) - Doses for X-ray and electron diffraction: New features in RADDOSE-3D including intensity decay models.
Dickerson, JL., McCubbin, PTN., Brooks-Bartlett, JC., Garman, EF.
Protein Sci 33(7): e5005. (30th June 2024) - Abandon the NAC in α-synuclein.
Goedert, M., Griesinger, C., Outeiro, TF., Riek, R., Schröder, GF., Spillantini, MG.
Lancet Neurol 23(7): 669. (30th June 2024) - Membraneless channels sieve cations in ammonia-oxidizing marine archaea.
von Kügelgen, A., et al.
Nature 630(8015): 230-236. (29th June 2024) - Mef2d potentiates type-2 immune responses and allergic lung inflammation.
Szeto, ACH., et al.
Science 384(6703): eadl0370. (28th June 2024) - Making cups and rings: the 'stalled-wave' model for macropinocytosis.
Kay, RR., Lutton, JE., King, JS., Bretschneider, T.
Biochem Soc Trans [Epub ahead of print]. (27th June 2024) - Outcomes of the EMDataResource cryo-EM Ligand Modeling Challenge.
Lawson, CL., et al.
Nat Methods [Epub ahead of print]. (25th June 2024)
See more Publications