The MRC Laboratory of Molecular Biology (LMB) is a research institute dedicated to the understanding of important biological processes at the levels of atoms, molecules, cells and organisms. In doing so, we provide knowledge needed to solve key problems in human health.
Our scientists tackle fundamental, often difficult and long-term research problems. The LMB has made revolutionary contributions to science, such as pioneering X-ray crystallography and electron cryo-microscopy (cryo-EM) to determine protein structures, the sequencing of DNA and the development of monoclonal antibodies. Twelve Nobel Prizes have been awarded for work carried out by LMB scientists.
The LMB also promotes the application and exploitation of our research findings, both by collaboration with existing companies and the founding of new ones, helping to advance medical research and the translation and application of knowledge.
The LMB provides an unsurpassed environment for both young and established researchers, with state-of-the-art facilities and a unique scientific culture. The LMB has always been very diverse, with a truly international outlook. We currently employ men and women from over 50 countries, and LMB alumni work in research organisations across the world.
Alessandra Stangherlin (O’Neill group) found a cellular mechanism that facilitates daily changes in heart rate. ~24h rhythms in Na/K/Cl levels osmotically compensate for daily changes in macromolecular crowding to modulate cardiac electrical activity, in vitro and in vivo.
Tau structures from range of neurological diseases revealed through cryo-EM analysis suggests a new way to characterise tauopathies on the basis of filament folds.
- Michel Goedert awarded the 2021 Hartwig Piepenbrock-DZNE Prize
Michel Goedert has been awarded the 2021 Hartwig Piepenbrock-DZNE prize for his work on the molecular mechanisms of neurodegenerative diseases, including Alzheimer’s and Parkinson’s. […]
- Jane Randall (1958 – 2021)
Jane Randall, former Assistant Divisional Administrator in the LMB’s PNAC Division, who for over 26 years was the welcoming face for many staff, students and visitors, died on Friday 8th October 2021. […]
- Single-cell transcriptomics of suprachiasmatic nuclei reveal a Prokineticin-driven circadian network.
Morris, EL., Patton, AP., Chesham, JE., Crisp, A., Adamson, A., Hastings, MH.
EMBO J 40(20): e108614. (18th October 2021)
- Oncogenic instructs morphological transformation of human epithelia via differential tissue mechanics.
Nyga, A., et al.
Sci Adv 7(42): eabg6467. (15th October 2021)
- Crystallographic approach to fragment-based hit discovery against Schistosoma mansoni purine nucleoside phosphorylase.
Faheem, M., et al.
Biochem J 478(19): 3655-3670. (15th October 2021)
- Large-scale movement of eIF3 domains during translation initiation modulate start codon selection.
Llácer, JL., Hussain, T., Dong, J., Villamayor, L., Gordiyenko, Y., Hinnebusch, AG.
Nucleic Acids Res [Epub ahead of print]. (14th October 2021)
- Restoring the Molecular Clockwork within the Suprachiasmatic Hypothalamus of an Otherwise Clockless Mouse Enables Circadian Phasing and Stabilization of Sleep-Wake Cycles and Reverses Memory Deficits.
Maywood, ES., Chesham, JE., Winsky-Sommerer, R., Hastings, MH.
J Neurosci 41(41): 8562-8576. (13th October 2021)
- Thermally Driven Membrane Phase Transitions Enable Content Reshuffling in Primitive Cells.
Rubio-Sánchez, R., et al.
J Am Chem Soc 143(40): 16589-16598. (13th October 2021)
- Prebiotic photoredox synthesis from carbon dioxide and sulfite.
Liu, Z., Wu, LF., Kufner, CL., Sasselov, DD., Fischer, WW., Sutherland, JD.
Nat Chem [Epub ahead of print]. (11th October 2021)
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