The MRC Laboratory of Molecular Biology (LMB) is a research institute dedicated to the understanding of important biological processes at the levels of atoms, molecules, cells and organisms. In doing so, we provide knowledge needed to solve key problems in human health.
Our scientists tackle fundamental, often difficult and long-term research problems. The LMB has made revolutionary contributions to science, such as pioneering X-ray crystallography and electron cryo-microscopy (cryo-EM) to determine protein structures, the sequencing of DNA and the development of monoclonal antibodies. Twelve Nobel Prizes have been awarded for work carried out by LMB scientists.
The LMB also promotes the application and exploitation of our research findings, both by collaboration with existing companies and the founding of new ones, helping to advance medical research and the translation and application of knowledge.
The LMB provides an unsurpassed environment for both young and established researchers, with state-of-the-art facilities and a unique scientific culture. The LMB has always been very diverse, with a truly international outlook. We currently employ men and women from over 50 countries, and LMB alumni work in research organisations across the world.
Jason Chin’s group, in our PNAC Division, has created cells with a synthetic genome and instructed them to make novel polymers from artificial building blocks for the first time. These new bacteria have also proved resistant to viral infections.
AMPA receptors mediate fast excitatory signal transmission and are created from combinations of subunits in a tissue-specific manner. Ingo Greger’s group provides the first visualisations of a hippocampal AMPA receptor involved in memory formation, with two auxiliary subunits.
- Wasi Faruqi awarded MBE in Queen’s Birthday Honours
Wasi (Abdul Raffey) Faruqi, from the LMB’s Structural Studies Division, has been made a MBE in the Queen’s 2021 Birthday Honours List […]
- Laura Pellegrini wins 3Rs Prize for the development of a brain barrier organoid
Laura Pellegrini, a postdoc in Madeline Lancaster’s group, has been awarded the 3Rs Prize for her paper investigating cerebrospinal fluid production using brain organoids. […]
- The global and promoter-centric 3D genome organization temporally resolved during a circadian cycle.
Furlan-Magaril, M., et al.
Genome Biol 22(1): 162. (8th June 2021)
- The relationship between birth timing, circuit wiring, and physiological response properties of cerebellar granule cells.
Shuster, SA., et al.
Proc Natl Acad Sci U S A 118(23). (8th June 2021)
- Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanoma.
Jacquelot, N., et al.
Nat Immunol [Epub ahead of print]. (7th June 2021)
- Nuclear envelope remodelling during mitosis.
Dey, G., Baum, B.
Curr Opin Cell Biol 70: 67-74. (6th June 2021)
- NF-κB Rel Subunit Exchange on a Physiological Timescale.
Biancalana, M., Natan, E., Lenardo, MJ., Fersht, AR.
Protein Sci [Epub ahead of print]. (4th June 2021)
- Unveiling the sensory and interneuronal pathways of the neuroendocrine connectome in .
Hückesfeld, S., et al.
Elife 10. (4th June 2021)
- Sense codon reassignment enables viral resistance and encoded polymer synthesis.
Robertson, WE., et al.
Science 372(6546): 1057-1062. (4th June 2021)
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