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About Us
The MRC Laboratory of Molecular Biology (LMB) is a research institute dedicated to the understanding of important biological processes at the levels of atoms, molecules, cells and organisms. In doing so, we provide knowledge needed to solve key problems in human health.
Our scientists tackle fundamental, often difficult and long-term research problems. The LMB has made revolutionary contributions to science, such as pioneering X-ray crystallography and electron cryo-microscopy (cryo-EM) to determine protein structures, the sequencing of DNA and the development of monoclonal antibodies. Twelve Nobel Prizes have been awarded for work carried out by LMB scientists.
The LMB also promotes the application and exploitation of our research findings, both by collaboration with existing companies and the founding of new ones, helping to advance medical research and the translation and application of knowledge.
The LMB provides an unsurpassed environment for both young and established researchers, with state-of-the-art facilities and a unique scientific culture. The LMB has always been very diverse, with a truly international outlook. We currently employ men and women from over 50 countries, and LMB alumni work in research organisations across the world.
Insight on Research
New insights into genetic mechanisms involved in kidney development

John-Poul Ng-Blichfeldt and Katja Röper, in the LMB’s Cell Biology Division, have collaborated with Julie Williams from AstraZeneca, to use renal organoids to investigate the human mesenchymal-to-epithelial transition, crucial to the morphogenesis of kidneys.
Phosphatase study solves substrate recruitment puzzle

Anne Bertolotti’s group in the LMB Neurobiology Division have revealed the substrate recruitment mechanism of major phosphatase non-catalytic subunit, PPP1R15B, by using full-length eIF2 and a combination of approaches.
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Latest News
Celebrating the success of the LMB’s inaugural Technician WeekThe first Technician Week included daily events aimed at technicians and technical specialists, open to all LMB staff. There were talks about professional registration, careers, and public engagement. […]
LMB receives silver LEAF accreditation for sustainable laboratory practicesThe accreditation is awarded to laboratories that can demonstrate practical steps towards improved efficiency and sustainability. […]
Latest Publications
- The role of filamentous matrix molecules in shaping the architecture and emergent properties of bacterial biofilms.
Böhning, J., Tarafder, AK., Bharat, TAM.
Biochem J 481(4): 245-263. (21st February 2024) - Crystal structure and biochemical activity of the macrodomain from rubella virus p150.
Stoll, GA., Nikolopoulos, N., Zhai, H., Zhang, L., Douse, CH., Modis, Y.
J Virol 98(2): e0177723. (20th February 2024) - Principles of microscopy for ophthalmologists.
Amos, WB.
Eye (Lond) [Epub ahead of print]. (19th February 2024) - The Suprachiasmatic Nucleus at 50: Looking Back, Then Looking Forward.
Ono, D., Weaver, DR., Hastings, MH., Honma, KI., Honma, S., Silver, R.
J Biol Rhythms : 7487304231225706 [Epub ahead of print]. (16th February 2024) - Cryo-EM of soft-landed β-galactosidase: Gas-phase and native structures are remarkably similar.
Esser, TK., et al.
Sci Adv 10(7): eadl4628. (16th February 2024) - Increased left ventricular remodelling index in paradoxical low-flow severe aortic stenosis with preserved left ventricular ejection fraction compared to normal-flow severe aortic stenosis.
Ngiam, JN., et al.
Singapore Med J [Epub ahead of print]. (16th February 2024) - PNMA2 forms immunogenic non-enveloped virus-like capsids associated with paraneoplastic neurological syndrome.
Xu, J., et al.
Cell 187(4): 831-845.e19. (15th February 2024)
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