About Us
The MRC Laboratory of Molecular Biology (LMB) is a research institute dedicated to the understanding of important biological processes at the levels of atoms, molecules, cells and organisms. In doing so, we provide knowledge needed to solve key problems in human health.
Our scientists tackle fundamental, often difficult and long-term research problems. The LMB has made revolutionary contributions to science, such as pioneering X-ray crystallography and electron cryo-microscopy (cryo-EM) to determine protein structures, the sequencing of DNA and the development of monoclonal antibodies. Twelve Nobel Prizes have been awarded for work carried out by LMB scientists.
The LMB also promotes the application and exploitation of our research findings, both by collaboration with existing companies and the founding of new ones, helping to advance medical research and the translation and application of knowledge.
The LMB provides an unsurpassed environment for both young and established researchers, with state-of-the-art facilities and a unique scientific culture. The LMB has always been very diverse, with a truly international outlook. We currently employ men and women from over 50 countries, and LMB alumni work in research organisations across the world.
Insight on Research
Revealing the hidden switch behind aggressive cancers

By capturing the first high-resolution structure of ADGRL4 in its active state, David Favara in Chris Tate’s group in the LMB’s Structural Studies Division has identified how a G-protein couples and revealed its activation method, paving the way for new cancer therapies.
Distinct AMPA receptor sub-types reside within glial and neuronal cells of the cerebellum

Multidisciplinary study from Ingo Greger’s group in the LMB’s Neurobiology Division reveals the structures and subunit assembly of GluA4 AMPA receptors in the mammalian cerebellum that support cell-type specific functions.
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Latest News
2026 Max Perutz Lecture to be given by Dirk GörlichThe 2026 Max Perutz Lecture titled ‘Transport through nuclear pores’ will be given by Dirk Görlich at 11am (GMT) on 19th January. […]
Neil Sands appointed Stores ManagerNeil Sands joined the LMB just over a year ago as the new Stores Manager, overseeing the inspection, receipting, handling, storage and distribution of all deliveries into the LMB. […]
Latest Publications
- An NSP2-MYB module orchestrates flavonoid biosynthesis and nodule symbiosis.
Gao, JP., et al.
Curr Biol [Epub ahead of print]. (4th February 2026) - Multi-omic analysis of guided and unguided forebrain organoids reveals differences in cellular composition and metabolic profiles.
Øhlenschlæger, MS., et al.
Cell Rep Methods : 101295 [Epub ahead of print]. (4th February 2026) - Organizers in a dish: Modeling human CNS morphogenesis.
Miller, G., et al.
Dev Cell [Epub ahead of print]. (4th February 2026) - Crystal structure of a tRNA acceptor-stem mimic at 1.94 Å resolution.
Liu, Z., Bellini, D., Gorrec, F., Wagner, A., El Omari, K., Sutherland, JD.
Acta Crystallogr F Struct Biol Commun 82(Pt 2): 57-65. (1st February 2026) - Author Correction: Hypoxia induces histone clipping and H3K4me3 loss in neutrophil progenitors resulting in long-term impairment of neutrophil immunity.
Sanchez-Garcia, MA., et al.
Nat Immunol 27(2): 377. (31st January 2026) - Weathering the Storm: The Impact of Weather Events, Lockdowns and Holidays on Oncology and General Emergency Presentations to a United Kingdom Tertiary Centre: A 7.5-year Review.
Favara, DM.
Clin Oncol (R Coll Radiol) 49: 103991. (29th January 2026) - The host protein cyclophilin A restricts nuclear entry of HIV-1 mutants by reducing the elasticity of the viral capsid.
Hong, J., et al.
PLoS Pathog 22(1): e1013910. (29th January 2026)
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