How did life first originate on this planet? Even the most minimal cell needs three subsystems: to convey information, to create compartments, and to catalyse metabolic reactions. But did these all arise together at the origin of life? Or did one form first? How could the molecules that create these subsystems assemble in the first […]
Insight on Research
Dynactin complex structure revealed by electron cryo-microscopy
Dynactin is a protein complex that activates the dynein motor protein, enabling intracellular transport. It is extremely flexible and has proved very difficult to study by conventional crystallography methods. Now for the first time, research carried out by Andrew Carter and his group in the LMB’s Structural Studies Division, has revealed the structure of this […]
Unfinished proteins: how to find a needle in the haystack
A research team from the LMB’s Cell Biology division, working with colleagues from the Structural Studies division, has revealed how cells are able to find and tag for degradation the partially synthesised proteins generated when ribosomes occasionally stall. Cells make more than a hundred thousand new proteins every minute. Once in a while, one of […]
Insight into bacterial cell division: Architecture of the FtsZ ring
When a bacterial cell divides, the cell membrane and cell envelope have to pinch together in the middle of the cell to separate it into two daughter cells. A ring of proteins called the divisome constricts, cleaving the cell in two. The protein FtsZ is a crucial component of this ring and many FtsZ subunits […]
Golden grids for electron cryo-microscopy
Recent exciting advances in electron cryo-microscopy (cryo-EM) have allowed scientists to find very detailed structures of some proteins. Still, determining the structure of many proteins remains too difficult for cryo-EM, as the images are too noisy to use for structure determination. Lori Passmore and Chris Russo from the LMB’s Structural Studies Division have designed new […]
Signposts for organelle identity – new Rab GTPase effectors found
Cells contain specialised membrane-bound compartments called organelles, which are vital to the cell as they allow it to separate different biochemical reactions that otherwise might interfere with each other. To function correctly, these intracellular compartments need to recruit proteins from the cytoplasm, and since every organelle has a specific role, each one needs a particular […]