Scientific Seminars

Below is a list of upcoming seminars at the LMB aimed at a general scientific audience and open to individuals throughout Cambridge. If you are not at the LMB and wish to attend a seminar, please contact Nikki Dominguez.

The LMB hosts ‘The LMB Seminar Series’, where 1-2 leading scientists per month are invited to speak throughout the year. Four of these lectures are named in honour of LMB Nobel Laureates Max Perutz, Francis Crick, César Milstein and John Kendrew, given by eminent scientists from around the world. The LMB Seminar talks and LMB Named Seminar talks are advertised widely throughout the local area and are open to all.

2017 LMB Seminar Series speakers (click to expand)

  • Jane Clarke – 11am, 23rd January
  • Thomas Sudhof – 4pm, 9th February (Milstien Lecture)
  • Carol Robinson – 11am, 7th March
  • Michaela Frye – 11am, 24th March
  • Caroline Dean – 4pm, 27th April (2016 Perutz Lecture)
  • Marc Kirschner – 4th May
  • Dan Durocher – 11am, 15th May
  • Chris Lima – 14th July
  • Patrick Cramer – 4pm, 5th September
  • Jack Szostak – 4pm, 7th September (Crick Lecture)
  • Erin O’Shea – 11am, 15th November (Perutz Lecture)

 

A full list of LMB Named Lectures to date can be found here.

Details of other local seminars can be found here


  • Mode Hopping and Arnold Tongues in Cell Dynamics

    Speaker: Doctor Mogens Jensen, Niels Bohr Institute, University of Copenhagen, Denmark
    Host: Madan Babu Mohan, MRC LMB
    Date: 27/03/2017 at 2:15pm in the Klug Seminar Room, Level 2, LMB.

    Further information

    Oscillating genetic patterns have been observed in networks related to thetranscription factors NFkB, p53 and Hes1. We have identified the central feed-back loops leading to oscillations. By applying an external periodic signal, it is possible to lock the internal oscillation to the external signal. For the NF-kB systems in single cells we have observed that the two signals lock when the ration between the two frequencies is close to basicrational numbers [1]. The resulting response of the cell can be mapped out as Arnold tongues. When the tongues start to overlap we may observe a chaotic dynamics of the concentration in NF-kB [1]. The group of Savas Tay (ETH, Zurich) has in single cell dynamics of the NF-kB system observed transitions from one tongue to the other when they overlap. We investigate this effect by Gillespie simulations and observe mode hopping transitions between different tongues in good agreement with the experiments [2]. The distribution of waiting times between subsequent mode hoppings follow a stretched exponential indicating strong correlations. The mode hopping dynamics in the stochastic system resembles very much the chaotic dynamics of the deterministic system [2].

  • Insights into ligand recognition and desensitization from the x-ray structure of a nicotinic receptor

    Speaker: Ryan Hibbs, UT Southwestern
    Host: Radu Aricescu
    Date: 30/03/2017 at 10:00am in the Max Perutz Lecture Theatre, LMB.

    Further information

    Nicotinic acetylcholine receptors are ligand gated ion channels that mediate fast chemical neurotransmission at the neuromuscular junction and play diverse signaling roles in the central nervous system. The vast majority of these and other pentameric receptors in the superfamily assemble as obligate heteromers. Here I will present methods we developed for expression and biochemical characterization of heteromeric
    ion channels and present the first X-ray crystal structure of a nicotinic
    receptor.
    The α4β2 nicotinic receptor that we characterized structurally is the most abundant receptor subtype in the brain, is the principal target in nicotine addiction and its dysfunction is associated with familial epilepsy. The structure of the receptor in complex with the agonist nicotine reveals principles of ligand selectivity among different classes of subunit interfaces in the heteropentameric assembly. The receptor is stabilized by nicotine in what we suggest is a non-conducting, desensitized conformation. The constriction point in the permeation pathway is formed at the selectivity filter, located at the cytosolic end of the pore. The desensitized state of this channel provides a distinct structural reference point in the allosteric gating cycle of the larger Cys-loop receptor superfamily.

  • Max Perutz Lecture- Antisense transcription and epigenetic switching

    Speaker: Caroline Dean, John Innes Centre, Norwich
    Host: Mariann Bienz
    Date: 27/04/2017 at 11:00am in the Max Perutz Lecture Theatre, LMB.


  • Clare Hall King Lecture- Title to follow

    Speaker: Marc Kirschner, Harvard Medical School
    Host: Lori Passmore
    Date: 04/05/2017 at 4:00pm in the Max Perutz Lecture Theatre, LMB.


  • LMB Seminar Series- Title to follow

    Speaker: Jennifer Lippincott-Schwartz, National Institute of Health, Maryland, USA
    Host: Ben Nichols and Bill Schafer
    Date: 08/05/2017 at 4:00pm in the Max Perutz Lecture Theatre, LMB.


  • Annual Sir John Walker Lecture

    Speaker:
    Host: MRC Mitochondrial Biology Unit- Penny Peck
    Date: 11/05/2017 at 4:30pm in the Max Perutz Lecture Theatre, LMB.


  • LMB Seminar Series- Title to follow

    Speaker: Dan Durocher, University of Toronto, Faculty of Medicine
    Host: Lori Passmore
    Date: 15/05/2017 at 11:00am in the Max Perutz Lecture Theatre, LMB.


  • LMB cryo-EM course - Past, present and future of cryo-EM

    Speaker: Richard Henderson, MRC LMB
    Host: Sjors Scheres, MRC LMB
    Date: 19/06/2017 at 9:30am in the Max Perutz Lecture Theatre, LMB.


  • LMB cryo-EM course - Physics and Optics

    Speaker: Chris Russo, MRC LMB
    Host: Sjors Scheres, MRC LMB
    Date: 20/06/2017 at 9:30am in the Max Perutz Lecture Theatre, LMB.


  • LMB cryo-EM course - Image formation, Fourier transform, CTF

    Speaker: Paula da Fonseca, MRC LMB
    Host: Sjors Scheres, MRC LMB
    Date: 21/06/2017 at 9:30am in the Max Perutz Lecture Theatre, LMB.


  • LMB cryo-EM course - Data acquisition

    Speaker: Christos Savva, MRC LMB
    Host: Sjors Scheres, MRC LMB
    Date: 22/06/2017 at 9:30am in the Max Perutz Lecture Theatre, LMB.


  • LMB cryo-EM course - Sample preparation

    Speaker: Lori Passmore, MRC LMB
    Host: Sjors Scheres, MRC LMB
    Date: 23/06/2017 at 9:30am in the Max Perutz Lecture Theatre, LMB.


  • LMB cryo-EM course - Image refinement

    Speaker: Sjors Scheres, MRC LMB
    Host: Sjors Scheres, MRC LMB
    Date: 26/06/2017 at 9:30am in the Max Perutz Lecture Theatre, LMB.


  • LMB cryo-EM course - Data analysis strategy

    Speaker: Rafael Fernandez Leiro, MRC LMB
    Host: Sjors Scheres, MRC LMB
    Date: 27/06/2017 at 9:30am in the Max Perutz Lecture Theatre, LMB.


  • LMB cryo-EM course - Modelling and validation

    Speaker: Alan Brown, MRC LMB
    Host: Sjors Scheres, MRC LMB
    Date: 28/06/2017 at 9:30am in the Max Perutz Lecture Theatre, LMB.


  • LMB cryo-EM course - Tomography

    Speaker: John Briggs, MRC LMB
    Host: Sjors Scheres, MRC LMB
    Date: 29/06/2017 at 9:30am in the Max Perutz Lecture Theatre, LMB.


  • LMB cryo-EM course - Our facility and training

    Speaker: Shaoxia Chen/Giuseppe Cannone, MRC LMB
    Host: Sjors Scheres, MRC LMB
    Date: 30/06/2017 at 9:30am in the Max Perutz Lecture Theatre, LMB.


  • Annual AWiSE-LMB Lunchtime Careers Meeting

    Speaker: Various
    Host: Cambridge AWiSE-LMB
    Date: 30/06/2017 at 11:00am in the Max Perutz Lecture Theatre, LMB.

    Further information

    More info to follow including registration

  • LMB Seminar Series- Title to follow

    Speaker: Chris Lima
    Host: David Komander
    Date: 14/07/2017 at 11:00am in the Max Perutz Lecture Theatre, LMB.


  • LMB Seminar Series-Title to follow

    Speaker: Patrick Cramer, Max Planck Institute
    Host: Phil Holliger
    Date: 05/09/2017 at 11:00am in the Max Perutz Lecture Theatre, LMB.


  • Crick Lecture-title to follow

    Speaker: Jack Szostack, Harvard, USA
    Host: Phil Holliger
    Date: 07/09/2017 at 4:00pm in the Max Perutz Lecture Theatre, LMB.


  • Max Perutz Lecture

    Speaker: Erin O Shea, Howard Hughes Medical Institute
    Host: Liz Miller
    Date: 15/11/2017 at 11:00am in the Max Perutz Lecture Theatre, LMB.