Scientific Seminars

Below is a list of upcoming seminars at the LMB aimed at a general scientific audience and open to individuals throughout Cambridge. If you are not at the LMB and wish to attend a seminar, please contact Nikki Dominguez.

The LMB hosts ‘The LMB Seminar Series’, where 1-2 leading scientists per month are invited to speak throughout the year. Four of these lectures are named in honour of LMB Nobel Laureates Max Perutz, Francis Crick, César Milstein and John Kendrew, given by eminent scientists from around the world. The LMB Seminar talks and LMB Named Seminar talks are advertised widely throughout the local area and are open to all.

2017 LMB Seminar Series speakers (click to expand)

  • Gillian Griffiths – 11am, 19th September
  • Susan Lea – 11am, 2nd October
  • Bart de Strooper – 11am, 25th October
  • Erin O’Shea – 11am, 15th November (Perutz Lecture)
  • Michelle Dunstone – 12th December

 

A full list of LMB Named Lectures to date can be found here.

Details of other local seminars can be found here


  • Engineering fluorescence for cell biology

    Speaker: Nick Dolman, Senior Staff Scientist, Thermo Fisher Scientific
    Host: Magda Sutcliffe
    Date: 20/09/2017 at 3:00pm in the Max Perutz Lecture Theatre, LMB.

    Further information

    The combination of light microscopy and fluorescent reporters offers an unparalleled view into the function of intact cells. Recently, the scientific community has witnessed many major innovations in fluorescence microscopy that have paved the way for exciting new discoveries. Invitrogen Molecular Probes reagents have represented a significant aspect of these key innovations, driving cutting edge of fluorescent reporter development for four decades. In this seminar, we will highlight the breadth and depth of fluorescent probes available to the cell biologist of today, drawing on specific techniques as diverse as single molecule and in vivo imaging to high content and multicolor time lapse imaging. Specific examples of assays to visualize key aspects of cell biology will also be described that include cytoskeletal dynamic, cell tracing, endocytosis, proliferation, autophagy, oxidative stress, and apoptosis. Furthermore, we will provide an overview of new probes and current constraints in serving emerging areas such as 3-D cellular models, high-content imaging and super resolution microscopy.

  • Close Species Comparative Genomics (CSCG) and Covolution

    Speaker: Professor Jong Park, Ulsan National Institute of Science & Technology, South Korea
    Host: Julian Gough, MRC LMB
    Date: 22/09/2017 at 11:00am in the Klug Seminar Room, Level 2, LMB.

    Further information

    CSCG (close species comparative genomics) is an approach of finding causative and highly influencing genetic variations for functions in species.In comparing genomes, it is critical to select the approapriate genetic distances among the genomes to detect certain causative geno-phenotypes. For examples, to detect the exact causative genetic mutation for white tigers, it is necessary to compare very closely related tiger genomes with a clear phenotypical difference. To detect the causative mutation for deep diving whales, it is necessary to select a proper background genomes which do not dive. Causative mutations are thought to be naturally selected to be transmitted by individuals to the next generations. Darwinian natural selection is a powerful descriptive theory for the propagation of life. However, there are evidence of Lamarckian inheritance in terms of epigenomics. Evolution theory has been changing since the time of Darwin. I speculate that there are causative mutations that are directed by the functional and behavioural advancement before naturally occuring random variations. This hypothetical directed and computed evolutionary mechanism is termed covolution. Comparing genomes which are the history books of life can bring the most definite new insights on how organisms evolve with and against environment.

  • Next Generation Biophysics

    Speaker: various
    Host: AstraZeneca and LMB
    Date: 27/09/2017 at 9:00am in the Max Perutz Lecture Theatre, LMB.

    Further information

    Free event but REGISTRATION IS ESSENTIAL TO ATTEND
    All information and registration here: https://www2.mrc-lmb.cam.ac.uk/groups/nextgen/

  • High-resolution AFM imaging of the organisation of proteins in native bacterial membranes.

    Speaker: Doctor Sandip Kumar, University of Sheffield
    Host: Chris Tate, MRC LMB
    Date: 28/09/2017 at 11:30am in the Milstein Seminar Room, Level 3, LMB.

    Further information

    Bacterial membranes are involved in multiple important functions like transportation, sensing, cell wall synthesis, etc. Most of these functions involve a supramolecular assembly of multiple proteins that interact with each other in ways that are strongly influenced by their spatial arrangement. Previously, AFM has been applied to native biological membranes that are flat (e.g. bacteriorhodopsin) or to membranes that had been flattened using detergents losing their native organisation (e.g. light-harvesting complex 2). Recent advances in AFM has made it possible to image native curved membranes. Chromatophores, vesicular photosynthetic membranes in Rhodobacter sphaeroides, were imaged in its native curved state at a resolution where even individual protein subunits are discernible (Kumar et al., ACS Nano, 2017, 11 (1), 126–133). As all chromatophores did not look the same, multiple chromatophores were imaged and the distances between the protein complexes were used to quantify their arrangement. These probable distances may assist in building an improved model of the system. Successive imaging of a chromatophore showed the proteins remain surprisingly static, with minimal rotation or translation. Novel, high order assemblies of RC-LH1-PufX complexes were observed, and intact ATPases were successfully imaged. The methods developed here are likely to be applicable to a broad range of protein rich native membrane systems and help understand their organisational functional relationship. AFM is an imaging technique which gives molecular and sub-molecular resolution with sufficient signal to noise such that averaging is not required. This gives it an advantage in imaging disordered systems. Some data will be presented showing the disordered architecture of biological surfaces like peptidoglycan cell wall of gram positive bacteria.

  • Evolution of olfactory receptors and circuits

    Speaker: Richard Benton, University of Lausanne
    Host: Greg Jefferis
    Date: 29/09/2017 at 2:00pm in the Max Perutz Lecture Theatre, LMB.


  • Stories from the first year of the Central Oxford Structural Microscopy and Imaging Centre - closing in on bacterial protein secretion systems.

    Speaker: Susan Lea, University of Oxford
    Host: Andrew Carter
    Date: 02/10/2017 at 11:00am in the Max Perutz Lecture Theatre, LMB.

    Further information

    Over the last year we have been installing cryo-electron microscopes in the centre of Oxford and learning about sample preparation and optimisation along the way. Our goal is to study a variety of systems but we have been concentrating on studies of bacterial protein secretion systems in the first instance. I'll present our current progress in study of Tat and Type Three protein secretion systems and point to future directions.



  • Max Perutz Lecture

    Speaker: Erin O Shea, Howard Hughes Medical Institute
    Host: Liz Miller
    Date: 15/11/2017 at 11:00am in the Max Perutz Lecture Theatre, LMB.


  • LMB Seminar Series- Title to follow

    Speaker: Erin O’Shea
    Host: Liz Miller
    Date: 15/11/2017 at 11:00am in the Max Perutz Lecture Theatre, LMB.


  • Regulation of DNA replication by checkpoint kinases after damage and during vertebrate development

    Speaker: Doctor Phil Zegerman, Gurdon Institute Cambridge
    Host: Lori Passmore, MRC LMB
    Date: 17/11/2017 at 11:00am in the Klug Seminar Room, Level 2, LMB.

    Further information

    DNA damage or replication stress during S-phase activates a checkpoint that executes multiple responses, including the inhibition of replication initiation and the stabilisation of replication forks. This checkpoint is essential for coordinating genome duplication and cell survival in the face of genotoxins and is a key target of existing and emerging chemotherapies. Significantly this checkpoint is also activated during normal development across many metazoa. Despite this, the functions of the S-phase checkpoint after DNA damage and during development are poorly understood. Here I will present a unifying mechanism to explain how the checkpoint kinase Rad53 is targeted to both replication initiation complexes and DNA replication forks in the budding yeast S.cerevisiae. In addition, I will describe our work in Xenopus laevis demonstrating that developmental activation of the checkpoint kinase Chk1 results in the degradation of a key limiting replication initiation factor Drf1 at the mid-blastula transition (MBT). Inhibition of Drf1 is a critical function of Chk1 at the blastula to gastrula stage of development and is the primary mechanism by which Chk1 blocks cell cycle progression in the early embryo. Together these studies uncover mechanisms that target the checkpoint kinases to their substrates and provide novel essential functions for these kinases in vivo.

  • Neural Mechanisms for Dynamic Acoustic Communication in Flies

    Speaker: Mala Murthy, Associate Professor, Princeton Neuroscience Institute, Princeton University
    Host: Greg Jefferis
    Date: 07/12/2017 at 10:30am in the Sanger Seminar Room, Level 3, LMB.

    Further information

    Social interactions require continually adjusting behavior in response to sensory feedback. For example, when having a conversation, sensory cues from our partner (e.g., sounds or facial expressions) affect our speech patterns in real time. Our speech signals, in turn, are the sensory cues that modify our partner’s actions. What are the underlying computations and neural mechanisms that govern these interactions? To address these questions, my lab studies the acoustic communication system of Drosophila. To our advantage, the fly nervous system is relatively simple, with a wealth of genetic tools to interrogate it. Importantly, Drosophila acoustic behaviors are highly quantifiable and robust. During courtship, males produce time-varying songs via wing vibration, while females arbitrate mating decisions. We discovered that, rather than being a stereotyped fixed action sequence, male song structure and intensity are continually sculpted by interactions with the female, over timescales ranging from tens of milliseconds to minutes – and we are mapping the underlying circuits and computations. We have also developed methods to relate song representations in the female brain to changes in her behavior, across multiple timescales. Our focus on natural acoustic signals, either as the output of the male nervous system or as the input to the female nervous system, provides a powerful, quantitative handle for studying the basic building blocks of communication.

  • Kendrew Lecture- Title to follow

    Speaker: Xiaowei Zhuang
    Host: Chris Russo
    Date: 15/01/2018 at 4:00pm in the Max Perutz Lecture Theatre, LMB.


  • The 6th Annual Sir John Walker Lecture

    Speaker: Professor Vamsi Mootha
    Host: MRC Mitochondrial Biology Unit
    Date: 22/02/2018 at 4:30pm in the Max Perutz Lecture Theatre, LMB.


  • LMB Seminar Series- Title to follow

    Speaker: Steve Harrison
    Host: Yorgo Modis
    Date: 28/06/2018 at 4:00pm in the Max Perutz Lecture Theatre, LMB.


  • Perutz Lecture- Title to follow

    Speaker: Eric Gouaux
    Host: Chris Tate
    Date: 29/11/2018 at 4:00pm in the Max Perutz Lecture Theatre, LMB.