Below is a list of upcoming seminars at the LMB aimed at a general scientific audience and open to individuals throughout Cambridge. If you are not at the LMB and wish to attend a seminar, please contact the seminar secretary.
The LMB hosts ‘The LMB Seminar Series’, where 1-2 leading scientists per month are invited to speak throughout the year. Four of these lectures are named in honour of LMB Nobel Laureates Max Perutz, Francis Crick, César Milstein and John Kendrew, given by eminent scientists from around the world. The LMB Seminar talks and LMB Named Seminar talks are advertised widely throughout the local area and are open to all.
2018 LMB Seminar Series speakers (click to expand)
- Sarah Teichmann – 11am, 15th November
- Carrie Partch – 11am, 20th November
- Eric Gouaux – 4pm, 29th November, Perutz Lecture
- Martin Beck – 11am, 3rd December
A full list of LMB Named Lectures to date can be found here.
Details of other local seminars can be found here
LMB Seminar Series- Reconstructing Tissue Architecture by Single Cell Genomics
Speaker: Sarah Teichmann
Host: Madan Babu
Date: 15/11/2018 at 11:00am in the Max Perutz Lecture Theatre, LMB.
Genomics has undergone a resolution revolution, such that the nucleic acid content of individual cells are now sequenced routinely in high-throughput mode. Thus we can define the cellular composition of tissues in an unbiased and comprehensive way using single cell transcriptomics, revealing the molecular fingerprint of cell states and their predicted signalling circuits in tissues across development and disease. I will illustrate this with the human healthy and asthmatic lung, as well as the maternal-fetal interface in the first trimester placenta/decidua
Immunology and Medicine Seminar Series: Harnessing Natural Killer cells against cancer.
Speaker: Adelheid Cerwenka
Host: Maike De La Roche, GSK
Date: 16/11/2018 at 1:00pm in the Max Perutz Lecture Theatre, LMB.
LMB Seminar Series - Morning larks and night owls: differences in human circadian rhythms shed light on the clock
Speaker: Carrie Partch, UC Santa Cruz
Host: John O’Neill
Date: 20/11/2018 at 11:00am in the Max Perutz Lecture Theatre, LMB.
Our lives are intimately tied to Earth’s 24-hour solar cycle through genetically encoded clocks that coordinate our physiology and behavior with environmental light/dark cycles. Disruption of circadian rhythms through shift work or jet lag can lead to metabolic disorders, cardiovascular disease, and cancer. Our lab studies how molecular clocks measure time on a daily basis to better understand how they use this information to coordinate and control our biology. I’ll speak about some recent advances from our lab using polymorphisms that give rise to morning lark and night owl behavior in people to shed light on the biochemical mechanisms of our molecular clock. Our long-term goal is to leverage a mechanistic understanding of clock function to develop therapeutic strategies that exploit circadian rhythms to improve human health and wellbeing.
Perutz Lecture- How synapses work: Architecture and mechanism of neurotransmitter receptors and transporters
Speaker: Eric Gouaux
Host: Chris Tate
Date: 29/11/2018 at 4:00pm in the Max Perutz Lecture Theatre, LMB.
Synapses are the electrical switches of the brain, underpinning much of the signaling between neurons and directly involved in nearly all aspects of innate and learned behaviors. The key signaling machinery – neurotransmitter receptors and transporters – are also implicated in a large number of neurological diseases or disorders and are the targets of multiple therapeutic agents and illicit substances. Synapses are sites of three choreographed processes – calcium-dependent release of neurotransmitter into extracellular spaces, detection of neurotransmitter by ion channels, and removal of neurotransmitter by transporters. In my talk I will focus on the last two activities.
On the one hand, binding of the released neurotransmitters to transmitter-gated ion channels initiates local changes in membrane potential and these changes, when summed, initiate action potentials that are propagated throughout neuronal circuits. On the other hand, the ion channels also allow for calcium entry into cells, thus initiating chemical signaling via calcium-dependent pathways. Quenching of the neurotransmitter within the synapse and surrounding spaces is accomplished by membrane-bound transporters, molecular machines that harness pre-existing ion gradients to ‘pump’ transmitter into cells, thereby enabling subsequent cycles of neurotransmitter signaling.
Here, I illuminate how neurotransmitters transduce binding events into the opening of ion channel-coupled receptors, and on the fascinating mechanisms by which neurotransmitter transporters take-up transmitter from the synaptic cleft and are modulated by clinically relevant drugs.
Immunology and Medicine Seminar Series: Dissecting the fibrotic niche of human liver cirrhosis using single cell transcriptomics.
Speaker: Neil Henderson, University of Edinburgh
Host: Menna Clatworthy, GSK
Date: 30/11/2018 at 1:00pm in the Max Perutz Lecture Theatre, LMB.
LMB Seminar Series - Title to Follow
Speaker: Martin Beck
Host: Wanda kukulsk
Date: 03/12/2018 at 12:00am in the Max Perutz Lecture Theatre, LMB.
Immunology and Medicine Seminar Series: Microbiome
Speaker: Janelle Ayres, Salk Institute for Biological Studies
Host: Lalita Ramakrishnan
Date: 05/12/2018 at 1:00pm in the Max Perutz Lecture Theatre, LMB.