Scientific Seminars

Below is a list of upcoming seminars at the LMB aimed at a general scientific audience and open to individuals throughout Cambridge. If you are not at the LMB and wish to attend a seminar, please contact the seminar secretary.

The LMB hosts ‘The LMB Seminar Series’, where 1-2 leading scientists per month are invited to speak throughout the year. Four of these lectures are named in honour of LMB Nobel Laureates Max Perutz, Francis Crick, César Milstein and John Kendrew, given by eminent scientists from around the world. The LMB Seminar talks and LMB Named Seminar talks are advertised widely throughout the local area and are open to all.

2018 LMB Seminar Series speakers (click to expand)

  • Yoshinori Fujiyoshi – 4pm, 13th September
  • Jordan Raff – 4pm, 20th September
  • Gero Miesenböck – 11am, 24th October, Crick Lecture
  • Sarah Teichmann – 11am, 15th November
  • Eric Gouaux – 4pm, 29th November, Perutz Lecture
  • Martin Beck – 11am, 3rd December

 

A full list of LMB Named Lectures to date can be found here.

Details of other local seminars can be found here


  • L-Type Ca2+ Channels in Brain Disorders

    Speaker: Prof. Jörg Striessnig, Institute of Pharmacy and Centre for Molecular Biosciences
    Host: Alex Pinggera
    Date: 24/09/2018 at 11:30am in the Sanger Seminar Room, Level 3, LMB.

    Further information

    Ca2+-channel blockers, such as the dihydropyridines (DHPs) amlodipine and isradipine, are clinically used for first-line treatment of hypertension and angina by inhibiting ion permeation through voltage-gated L-type Ca2+-channels (LTCCs, Cav1) in arterial smooth muscle and the heart. LTCCs are also key regulators of Ca2+-dependent signaling processes in the brain. In neurons Cav1.2 and Cav1.3 LTCC isoforms are located postsynaptically at dendrites and at the cell soma. They control neuronal excitability, synaptic morphology and couple synaptic activity to gene transcription. Through their distinct biophysical properties Cav1.2 and Cav1.3 contribute in different ways to various forms of learning, memory, emotional and drug-taking behaviours. Cav1.3 also appears to play a major role for the high Ca2+ -dependent vulnerability of Substantia nigra dopamine neurons in Parkinsons Disease.

    We have recently characterized three human disease-relevant de novo missense mutations in the pore-forming a1-subunit of Cav1.3 channels (CACNA1D), including gain-of-function mutations in three patients with sporadic autism spectrum disorder (ASD) with or without intellectual disability and neurological symptoms. Our recent finding of a fourth mutation in a patient with a severe, undiagnosed developmental disorder (DECIPHER DD cohort) adds CACNA1D to the list of major risk genes for neurodevelopmental disorders, including ASD. We have successfully generated a mouse model carrying one of the human ASD mutations (A749G). First results obtained with this mouse model confirm behavioral abnormalities consistent with behaviors observed in ASD patients. Brain-permeable LTCC inhibitors already in clinical use (e.g. isradipine, nimodipine) may therefore serve as promising therapeutics in individuals carrying such Cav1.3 gain-of-function mutations, a hypothesis that can be tested in A749G mice. However, we provide experimental evidence that the therapeutic window of DHPs may be limited, because isradipine inhibits Cav1.3 channels during simulated neuronal activity patterns with an order of magnitude lower potency than smooth muscle Cav1.2, its peripheral target for blood pressure lowering. Therefore, inhibition of neuronal LTCCs Ca2+ channels with existing LTCCblockers could be a novel option for the treatment of neuropsychiatric disease and perhaps also as a neuroprotectant in Parkinsons Disease. However, chronic treatment may require high maintenance doses likely to cause side effects in some patients.

  • Continuous imaging of entire circadian circuit at single cell resolution shows light inputs and phase shift transformations

    Speaker: Todd Holmes, UCI School of Medicine
    Host: Michael Hastings
    Date: 24/09/2018 at 2:00pm in the Klug Seminar Room, Level 2, LMB.


  • Next Generation Biophysics

    Speaker: Various
    Host: Stephen McLaughlin
    Date: 03/10/2018 at 9:00am in the Max Perutz Lecture Theatre, LMB.

    Further information

    Register at https://www2.mrc-lmb.cam.ac.uk/groups/nextgen/

    There will be 12 talks from speakers covering topics from fundamental technology and method development to the use of cutting edge biophysics in the pharmaceutical industry. There will be four main themes; Nucleic Acid Enzymes & Machines, Protein Conformation, New Technologies and Signaling. There will also be a keynote lecture from the LMB’s Richard Henderson in the area of cryoEM.

  • Cambridge 3Rs seminar series: Autumn 2018 meeting

    Speaker: Frank Uhimann, Francis Crick Institute
    Host: Martin Taylor (Yeeles Lab, LMB)
    Date: 04/10/2018 at 5:00pm in the Max Perutz Lecture Theatre, LMB.

    Further information

    Please register here https://www.eventbrite.co.uk/e/3rs-replication-repair-recombination-meeting-october-2018-tickets-49955268553

    External speaker: Frank Uhimann, Francis Crick Institute, London

  • Light Sleep

    Speaker: Gero Miesenbock
    Host: William Schafer
    Date: 24/10/2018 at 11:00am in the Max Perutz Lecture Theatre, LMB.

    Further information

    Gero Miesenböck is Waynflete Professor of Physiology and founding Director of the Centre for Neural Circuits and Behaviour at the University of Oxford. A native of Austria, Gero studied medicine at the University of Innsbruck and was a postdoctoral fellow with James Rothman. Before coming to Oxford in 2007, he held faculty appointments at Memorial Sloan-Kettering Cancer Center and Yale University School of Medicine.

    Gero has received many awards for the invention of optogenetics. He is a Fellow of the Royal Society and a member of the German and Austrian Academies of Science.

    His lecture, entitled "Light Sleep," will illustrate the enabling power of optogenetics with recent work on the homeostatic regulation of sleep. Optogenetic interventions have helped to pinpoint neurons whose sleep-inducing activity switches on as sleep deficits accrue, reveal how this activity switch works, and furnish a molecular interpretation of sleep pressure, its accumulation, and its discharge.

  • LMB Seminar Series - Title to follow

    Speaker: Max Gutierrez
    Host: Felix Randow
    Date: 01/11/2018 at 4:00pm in the Max Perutz Lecture Theatre, LMB.


  • LMB Seminar Series - Title to follow

    Speaker: Sarah Teichmann
    Host: Madan Babu
    Date: 15/11/2018 at 11:00am in the Max Perutz Lecture Theatre, LMB.


  • LMB Seminar Series - Title to follow

    Speaker: Carrie Partch, UC Santa Cruz
    Host: John O’Neill
    Date: 20/11/2018 at 11:00am in the Max Perutz Lecture Theatre, LMB.


  • Perutz Lecture- Title to follow

    Speaker: Eric Gouaux
    Host: Chris Tate
    Date: 29/11/2018 at 4:00pm in the Max Perutz Lecture Theatre, LMB.


  • LMB Seminar Series - Title to follow

    Speaker: Eric Gouaux
    Host: Christ Tate
    Date: 29/11/2018 at 4:00pm in the Max Perutz Lecture Theatre, LMB.