Setting the stage: development of sample holders for electron cryomicroscopy.
The advancement of microscope sample holders was crucial for moving from electron microscopy to electron cryo-microscopy (cryo-EM). Cryo-EM of amorphous (non-crystalline) ice embedded specimens is a method which allows the visualisation of biological molecules in a near-native state, requiring the preservation of the specimen at a temperature below -180oc (100 Kelvin) during microscopy. The exhibition features holders from the 1960s to the current day. Visitors can also learn about the scientists behind the work, see a video of Nobel laureate Richard Henderson showing a holder in use and an animation of the cryo-EM process.
July – October 2021
