EpsinR Home Page

These pages complement our paper on EpsinR published in 2003 (see paper)
Mills et al., J. Cell Biol. 160: 213-222 (2003)
The main focus here is a comparison between Epsin1 and EpsinR
For a detailed study of endogenous epsinR and overexpression of wild-type and mutants in cells see immunocytochemistry.

EpsinR binds to gamma-adaptin appendage domain with an affinity of 3.7microM, while epsin1 binds better to alpha and beta appendage domains.

Epsin1 co-localises with plasma membrane clathrin puncta, while epsinR co-localises with pericentriolar clathrin