Significant papers from the past

McMahon, H.T., Bolshakov, V.Y., Janz, R., Hammer, R.E., Siegelbaum, S. and Südhof, T.C. (1996) Synaptophysin, a major synaptic vesicle protein, is not essential for transmitter release. PNAS 93, 4760-4764.
 Mouse knock-out of the prominent synaptic vesicle protein, synaptophysin. Surprisingly the mice are still viable.

McMahon, H.T., Missler, M., Li,.C. and Südhof, T.C. (1995) Complexins: Cytosolic proteins that regulate SNAP receptor function. Cell 83, 111-119.

McMahon, H.T. and Südhof, T.C. (1995) Synaptic core complex of synaptobrevin, syntaxin and SNAP25 forms a high affinity alphaSNAP binding site.  J. Biol. Chem. 270, 2213-2217.

Hayashi, T., McMahon, H.T., Yamasake, S., Binz, T., Hata, Y., Südhof, T. C. and Niemann, H. (1994) Synaptic vesicle membrane fusion complex: Action of Clostridial neurotoxins on assembly.  EMBO J. 13, 5051-5061.

Ullrich, B.,  Li, C., Zhang, J.Z., McMahon, H.T., Anderson, R.G.W., Geppert, M. and Südhof, T.C. (1994)  Functional properties of multiple synaptotagmins in brain.  Neuron 13, 1020.

McMahon, H.T., Ushkaryov, Y.A., Edelmann, L., Link, E., Binz, T., Niemann, H., Jahn, J. and Südhof, T.C. (1993)  Cellubrevin is a ubiquitous tetanus-toxin substrate homologous to a putative synaptic vesicle fusion protein.  Nature 364, 346-349.  (see also News and Views)

Link, E., McMahon, H., Fischer von Mollard, G., Yamasaki, S., Niemann, H., Südhof, T.C. and Jahn, R. (1993) Cleavage of cellubrevin by tetanus toxin does not affect fusion of early endosomes. J.Biol.Chem. 268, 18423-18426.

Robinson, P.J., Sontag, J-M., Liu, J-P., Fyske, E.M., Slaughter, C., McMahon, H.T. and Südhof, T.C. (1993) Dynamin GTPase regulated by protein kinase C phosphorylation in nerve terminals. Nature 365, 163-166. (see also News and Views)

McMahon, H.T. and Nicholls, D.G. (1993) Barium-evoked glutamate release from guinea-pig cerebrocorical synaptosomes. J.Neurochem. 61, 110-115.

McMahon, H.T., Foran, P., Dolly, J.O., Verhage, M., Wiegant, V.M. and Nicholls, D.G. (1992) Tetanus and Botulinum toxins type A and B inhibit glutamate, GABA, aspartate and met-enkephalin release from synaptosomes: Clues to the locus of ac tion. J.Biol.Chem. 267, 21338-21343.

McMahon, H.T. and Nicholls, D.G. (1991) The Bioenergetics of Neurotransmitter Release (invited review). BBA 1059, 243-264.

McMahon, H.T. and Nicholls, D.G. (1991) Transmitter glutamate release from isolated nerve terminals: evidence for biphasic release and triggering by localized Ca2+. J. Neuroc hem. 56, 86-94.

Verhage, M., McMahon, H.T. Boomsna, Wiegant and Nicholls, D.G. (1991) Release of amino acids, cholecystokinin and noradrenaline from isolated hippocampal terminals show differing preferences for localised versus delocalised Ca2+ entry. Neuron 6, 517-524.

McMahon, H.T. and Nicholls, D.G. (1990) The relationship between cytoplasmic free Ca2+ and the release of glutamate from synaptosomes. Biochem. Soc. Trans. 18, 375-377.

McMahon, H.T., Rosenthal, L., Meldolesi, J and Nicholls, D.G. (1990) ?-Latrotoxin releases both vesicular and cytoplasmic glutamate from isolated nerve terminals. J. Neuroc hem. 55, 2039-2047.

McMahon,H.T. and Nicholls, D.G. (1990) Glutamine and aspartate loading of guinea pig cerebral cortical synaptosomes: a re-evaluation of effects on Ca2+-dependent excitatory amino acid release. J. Neurochem. 54, 373-380.

Kauppinen, R.A., McMahon, H.T., and Nicholls, D.G. (1990) The effects of experimental anoxia on glycolysis, energy status, cytosolic free calcium, and glutamate release from isolated nerve terminals, in Cerebral Ischaemia and Calcium (Hart mann A. and Kuschinsky W. eds.) Springer, Berlin.

McMahon, H.T., Barrie, A.P., Lowe, M. and Nicholls, D.G. (1989) Glutamate release from guinea pig synaptosomes: Extra-cellular glutamate may exert a positive feedback by reuptake-induced depolarisation rather than receptor activation. J. Neurochem. 53, 71-79.

Tibbs, G., Barrie, A.P., Van Mieghem F., McMahon, H.T. and Nicholls, D.G. (1989) Repetitive action potentials in isolated nerve terminals in the presence of 4-aminopyridine: effects on cytosolic free Ca2+ and glutamate release. J. Neurochem. 53, 1693-1699.

Kauppinen, R.A., McMahon H.T., and Nicholls, D.G. (1988) Calcium-dependent and calcium-independent glutamate release, energy status and cytosolic free calcium concentration in isolated nerve terminals following in vitro hypoglycaemia and a noxia. Neuroscience, 27, 175-182.

McMahon, H.T., Kauppinen, R. and Nicholls, D.G. (1988) The energetics of Ca-dependent release from synaptosomes and the effect of experimental anoxia, hypoglycaemia and ischaemia. Biochem. Soc. Trans. 16, 880-881.

Nicholls, D.G., Barrie, A.P., McMahon, H.T., Tibbs, G. and Wilkinson, R. (1988) Mechanisms of Glutamate Exocytosis from Isolated Nerve Terminals. In, Nato ASI Series H: Cell Biology: "Receptors, Membrane Transport and Signal Transduct ion" 29, 147-161.