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MRC Laboratory of Molecular Biology

MRC Laboratory of Molecular Biology

One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health.

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Eureka Moments: making proteins, making a difference

“In the second of the Biochemical Society’s video interviews with our Honorary Members, Michael Neuberger and Brian Hartley talk to Sir Greg Winter about his role as a pioneer of therapeutic antibodies.” More…

Published on 21st April, 2011

No DNA needed, RNA goes solo

“Philipp Holliger and his co-workers at LMB have engineered an RNA enzyme to synthesize another active RNA enzyme from an RNA template. This models one theory for how life originated on Earth: with RNA molecules that both encoded genetic information and catalysed reactions to express that information.” More…

Published on 21st April, 2011

Biologists create one of life’s first enzymes

“tC19Z, synthesised in Phil Holliger’s lab at LMB, could be a version of one of the first enzymes that ever existed on our planet – and a clue to how life itself got started.” More…

Published on 8th April, 2011

Heptares Therapeutics helps push GPCR drug discovery forward

Chemical & Engineering News (C&EN)

“G-protein-coupled receptors are hot drug targets, and plenty of companies want to know what they look like to get an edge on making new drugs. Despite recent advances, getting X-ray crystal structures for GPCRs is still far from easy. Heptares Therapeutics, joins a trio of firms in licensing their structure-determining technology and partnering with large drugmakers to help push GPCR drug discovery forward. Heptares Therapeutics obtains GPCR X-ray structures with help from thermal stabilization – a targeted mutation technique developed by Chris Tate and Richard Henderson at LMB.” More…

Published on 14th March, 2011

Max Perutz: his life and legacy

Guardian Logo

“LMB scientists take part in a round-table discussion about Max Perutz.” More…

Published on 8th March, 2011

Mariann Bienz talks about signalling pathways as a target for cancer therapies

“A number of signalling pathways discovered in Drosophila flies and other model organisms have subsequently turned out to be important in cancer and specifically in cancer stem cell function. Mariann Bienz talks about the role of the Wnt signalling pathway in cancer growth and cancer metastases but warns of difficulties developing therapies to target this pathway. Prof Bienz explains what progress has been made by academic labs working to develop therapies to target signalling pathways and explains the mechanisms through which the pathways can be affected.” More…

Published on 14th February, 2011
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