LMB In The News

Scientists establish a comprehensive protein interactions map of the replication machinery of a chronic virus

Chronic viral infections are amongst the biggest threats to human health worldwide. Leo James’ group from the LMB’s PNAC Division, in collaboration with scientists at the Austrian Academy of Sciences and University of Basel, have established the first comprehensive overview of cellular proteins interacting with the LCMV polymerase. It is hoped that the research leads to a better understanding of how chronic viral infections start and the complex molecular interactions between viruses and their hosts. More…


Distinct human mutations can alter the effect of medicine

University of Copenhagen logo

About one third of all medicine binds to the same type of receptor in the human body. An estimated 3 percent of the population have receptors of this type that are so genetically different that they are predisposed to altered, ineffective or adverse responses to medicine, a new study from the University of Copenhagen and the MRC Laboratory of Molecular Biology in Cambridge shows.  More…


GPCR structures aided drug design

Chemical & Engineering News (C&EN)

A decade after a key structural analysis, scientists have a better understanding of the pharmaceutically important family of receptor proteins – G protein-coupled receptors (GPCR).  Includes reference to the work done at the LMB by Chris Tate. More...


Potassium is critical to circadian rhythms in human red blood cells

An innovative new study from the University of Surrey and John O’Neill’s group from the LMB’s Cell Biology Division has uncovered the secrets of the circadian rhythms in red blood cells and identified potassium as the key to unravelling the mystery. More…


LMB postdoc, Tobias Wauer, wins the 2017 EMPRIS Award for Research in Brain Diseases

LMB postdoctoral researcher, Tobias Wauer, has won the 2017 EMPRIS Award for Research in Brain Diseases for his work on the molecular causes of Parkinson’s disease. In this interview, he explains his fascination for research. More…


LMB scientist, Glenn Masson, spends a week shadowing MP for Cambridge, Daniel Zeichner, through the Royal Society’s Pairing Scheme

Glenn Masson has spent a week shadowing Daniel Zeichner, MP for Cambridge, through the Royal Society’s Pairing Scheme, an initiative which pairs scientists with MPs to foster exchange of knowledge and understanding of politics, policy and science. More…


Trim-Away: a new technique for depleting proteins and studying their function

Dean Clift from Leo James’ group, in collaboration with LMB alumnus Melina Schuh at the Max Planck Institute, have developed a new technique – Trim-Away – which allows proteins to be rapidly depleted from cells. By harnessing the cells’ protein degradation machinery and TRIM21, the scientists have provided a new technique for studying protein function. More…


Finding the founding fathers of molecular biology – a blog post by LMB PhD student, Lisa Strittmatter

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Lisa Strittmatter, PhD student in the LMB’s Structural Studies Division, explores a recent talk given at the LMB by Professor Sir John Meurig Thomas, and the light it sheds on the key scientists involved in the origins of molecular biology. More…


Brain research in the third dimension

Madeline Lancaster, cell biologist at the MRC Laboratory of Molecular Biology in Cambridge, has developed a technique allowing her to create mini brains from cell cultures. These incredible organoids, no larger than the eraser at the end of a pencil, serve as a model for Madeline’s research into early human brain development and are enabling Madeline and her team to tackle the age-old question: what is it that distinguishes us as humans? More…


LMB scientist wins ‘Best Technology’ prize in the 2017 Biomaker Challenge

The LMB’s Wolfgang Schmied, in collaboration with Stéphanie Polderdijk from the Cambridge Institute for Medical Research, won ‘Best Technology’ prize in the 2017 Biomaker Challenge for developing a low-cost chromatography system for protein purification. The Challenge aims to show the value of open, low-cost and DIY technologies as convening points for interactions between biologists and engineers. More…