MRC Laboratory of Molecular Biology
One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health.
Dean Clift from Leo James’ group, in collaboration with LMB alumnus Melina Schuh at the Max Planck Institute, have developed a new technique – Trim-Away – which allows proteins to be rapidly depleted from cells. By harnessing the cells’ protein degradation machinery and TRIM21, the scientists have provided a new technique for studying protein function. More…
Lisa Strittmatter, PhD student in the LMB’s Structural Studies Division, explores a recent talk given at the LMB by Professor Sir John Meurig Thomas, and the light it sheds on the key scientists involved in the origins of molecular biology. More…
Madeline Lancaster, cell biologist at the MRC Laboratory of Molecular Biology in Cambridge, has developed a technique allowing her to create mini brains from cell cultures. These incredible organoids, no larger than the eraser at the end of a pencil, serve as a model for Madeline’s research into early human brain development and are enabling Madeline and her team to tackle the age-old question: what is it that distinguishes us as humans? More…
The LMB’s Wolfgang Schmied, in collaboration with Stéphanie Polderdijk from the Cambridge Institute for Medical Research, won ‘Best Technology’ prize in the 2017 Biomaker Challenge for developing a low-cost chromatography system for protein purification. The Challenge aims to show the value of open, low-cost and DIY technologies as convening points for interactions between biologists and engineers. More…
A new study led by John O’Neill and Ned Hoyle shows how bodyclocks in skin cells influence wound healing. More…
Lori Passmore and her group have used electron cryo-microscopy to solve the structure of CPF, a protein complex critical for gene expression. Understanding the structure and function of intact CPF, and how it is assembled, has been a central question in the field of gene expression for decades. [A Log-in or subscription may be required to view this article from the host site: https://www.drugtargetreview.com/news/27088/cryo-electron-microscopy-cpf/]