Electron Cryo-microscopy

LMB scientists have been and continue to be at the forefront of the field of electron cryo-microscopy, developing a technique which allows biological molecules to be visualised at the atomic level. In 2017 the LMB’s Richard Henderson won the Nobel Prize for Chemistry, along with Jacques Dubochet and Joachim Frank, for ‘developing cryo-electron microscopy for the high-resolution structure determination of biomolecules in solution’. Find out more about their Nobel Prize.

Electron Cryo-microscopy Film

Electron Cryo-microscopy in Research

Read about cutting edge research from the LMB that has used electron cryo-microscopy.

Atomic advance for cryo-EM

Freezing molecules completely still for cryo-EM

Catching the ribosome in the act of scanning mRNA

Studying the spike protein of SARS-CoV-2

First structures of α-synuclein filaments from human brain

Unravelling the replisome: how a molecular machine overcomes obstacles to DNA replication

First look at the atomic structure of thyroglobulin

Decade-long collaboration results in the first structure of the Fanconi anaemia core complex

Fast, simple, accessible and affordable: The future of cryo-EM