Patrycja Kozik’s group, in the LMB’s PNAC Division, find that the pore-forming protein perforin-2 is an effector of antigen escape in dendritic cells – a critical component to T cell mediated immune responses.
Pore-forming protein perforin-2 is critical to immune response by dendritic cells
Antiviral Bicycles are effective against SARS-CoV-2
A collaborative study including researchers in Leo James’ group in the LMB’s PNAC Division and Bicycle Therapeutics has developed a new class of antivirals which can be combined together like building blocks to effectively immobilise COVID-19’s Spike protein and block infection.
Neuroprotective protein ADNP is vital to immune reactions to allergens
Using high-throughput CRISPR screening, researchers in Andrew McKenzie’s group in the LMB’s PNAC Division have identified a previously unknown immune-related role for ADNP and identified the molecular mechanism by which it regulates IL-13 expression in allergic immune responses.
How flies use smell to determine the identity and position of other flies
Researchers from Greg Jefferis’ group in the LMB’s Neurobiology Division have determined the highly specified neural mechanisms which allow Drosophila flies to identify and locate males by scent of a pheromone.
Activating the kinase protein PI3Kα revealed as a potential therapeutic target to protect and regenerate cells
New pre-clinical research in Roger Williams’ group at MRC LMB, University College London and AstraZeneca discovers an activator of PI3Ka that can protect heart cells from dying in the case of injury and accelerate the regeneration of neurons
Understanding the protein modifications behind Trim-Away protein degradation technology
Leo James’ group, in the LMB’s PNAC Division, has identified surprising protein modifications that underly Trim-Away protein degradation technology, which may explain its broad applicability to degrade almost any cellular protein.