![GABAA receptors, which mediate essential signalling in the brain and beyond, can assemble into a much larger number of arrangements than previously anticipated. This diversity enables complex responses to both neurotransmitters and drugs. Image shows structures of GABAA receptors in variety of arrangements.](https://www2.mrc-lmb.cam.ac.uk/wordpress/wp-content/uploads/Front_web_page_square_Aricescu_Radu_Sente_Andrija_Nature_GABA_receptor_IoR-150x150.jpg)
Structural analysis of GABAA receptors by Radu Aricescu’s group, in the LMB’s Neurobiology Division, has revealed possibility for an unexpected variety in subunit arrangement, with significant implications for future research and therapeutic developments.