New pre-clinical research in Roger Williams’ group at MRC LMB, University College London and AstraZeneca discovers an activator of PI3Ka that can protect heart cells from dying in the case of injury and accelerate the regeneration of neurons
Activating the kinase protein PI3Kα revealed as a potential therapeutic target to protect and regenerate cells
Understanding the protein modifications behind Trim-Away protein degradation technology
Leo James’ group, in the LMB’s PNAC Division, has identified surprising protein modifications that underly Trim-Away protein degradation technology, which may explain its broad applicability to degrade almost any cellular protein.
The structure of the surface layer of the toughest bacterium known elucidated
Using electron microscopy, Tanmay Bharat’s group reveals the surface layer structure of the extremophilic bacterium, Deinococcus radiodurans.
Complete synaptic-resolution connectome of an insect larval brain
The groups of Marta Zlatic and Albert Cardona in the LMB’s Neurobiology Division have mapped the Drosophila larval brain, which contains 3016 neurons and 548,000 synapses and is the most complex brain ever mapped in its entirety.
Aggregation of proteins on cell surface triggers rapid uptake and degradation
Using a combination of light microscopy and biochemical assays, Harvey McMahon’s group, in the LMB’s Neurobiology Division, have identified aggregation-dependent endocytosis (ADE) as the pathway by which cells respond to surface perturbations.
New computational method for genome analysis
Julian Gough’s group, in the LMB’s Structural Studies Division, has designed a computational method for genome analysis capable of making knowledge-based predictions directly from a human genome.