A new study from Joe Yeeles’ group, in the LMB’s PNAC Division, demonstrates the first reconstitution of a functional human replisome that performs fast and efficient DNA replication.
Functional human replisome reconstituted for the first time
Proteins required for processing the end of mRNAs identified
Lori Passmore’s group in the LMB’s Structural Studies Division has shown that Mpe1 in yeast and RBBP6 in humans are critical for activating CPF and CPSF respectively, protein complexes vital to cleavage process of mRNA.
Human inner kinetochore structure reveals mechanism for binding DNA during mitosis
In solving the structure of the human inner kinetochore bound to a centromeric CENP-A nucleosome, David Barford’s group in the LMB’s Structural Studies Division has revealed how the complex recognises centromeric DNA and functions as a load-bearing element during chromosome segregation.
Structural study reveals unexpected diversity in GABAA receptor assembly
Structural analysis of GABAA receptors by Radu Aricescu’s group, in the LMB’s Neurobiology Division, has revealed possibility for an unexpected variety in subunit arrangement, with significant implications for future research and therapeutic developments.
TMEM106B filaments form in an age-dependent manner in human brains
Inter-divisional collaboration between the groups of Sjors Scheres, Michel Goedert and others identified TMEM106B as a new protein responsible for amyloid filament formation, and showed that these filaments develop in an age-dependent manner in human brains.
Structural study reveals a novel activation mechanism for the fungal GPCR, Ste2
Chris Tate’s group, in the LMB’s Structural Studies Division, have used cryo-EM analysis to show that Ste2, a fungal Class D GPCR, has a fundamentally distinct activation mechanism in comparison to other types of GPCRs.