![: Image of the replisome with bound ubiquitin ligase targeting the replisome for disassembly.](https://www2.mrc-lmb.cam.ac.uk/wordpress/wp-content/uploads/IoR_Yeeles_10-21_SquareCrop_500px_500px-150x150.jpg)
Disassembly of the DNA replication machinery, known as the replisome, is the final step of eukaryotic chromosome replication. A collaboration between Joe Yeeles’ group at the LMB and the Deegan lab in Edinburgh shows how replisome disassembly is regulated through ubiquitin ligase activity and stearic hindrance from the DNA itself.