New structure from Andrew Carter’s group in the LMB’s Structural Studies Division reveals dynein’s interaction with microtubules and how cargo adaptors use conserved sequence motifs to scaffold the motor protein complex
Cryo-EM reveals first high-resolution structure of the dynein-dynactin complex bound to microtubules
Mammalian clock gene Cryptochrome 1 is crucial to suprachiasmatic nucleus timekeeping
Using translational switching, Michael Hastings’ group has shown that the mammalian clock gene Cryptochrome 1 is a state variable and core phase setting component of the brain’s master clock.
New analysis approach to identify pathogenesis of Mycobacterium abscessus
Andres Floto’s group in the University of Cambridge’s Molecular Immunity Unit, housed at the LMB, have developed phenogenomic analysis – a combination of phenotyping and whole genome sequencing – as a new approach to reveal insights into bacterial pathobiology.
Cryo-EM structure of a cholinergic cell membrane reveals importance of cholesterol in neuromuscular transmission
Structural study by Nigel Unwin in the LMB’s Neurobiology Division, has found that lipids of cell membranes can form ordered, hydrophobic ‘skins’ in regions of high cholesterol concentration.
Pathway behind pathogenic mechanism of tuberculosis identified
New research from Lalita Ramakrishnan’s group, LMB Cell Biology Division and University of Cambridge Molecular Immunity Unit, has revealed the reverse electron transport pathway behind mitochondrial reactive oxygen species overproduction, contributing to tuberculosis pathogenesis.
Clinical study reveals striking daily temperature variation in the human brain that predicts survival after brain injury
A clinical study, led by Nina Rzechorzek in John O’Neill’s group at the LMB, showed that healthy human brain temperature varies far more than previously assumed—by age, sex, brain region, and time of day. This has major implications for patients, suggesting that daily rhythmic brain temperature variation is critical to brain function.