• Skip to primary navigation
  • Skip to main content
  • Skip to primary sidebar
MRC Laboratory of Molecular Biology

MRC Laboratory of Molecular Biology

One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health.

  • Home
  • About LMB
  • Research
  • Research Groups
  • Students
  • Recruitment
  • Life at the LMB
  • Achievements
  • News & Events
Home > News & Events > Insight on Research

Insight on Research

  • All
  • 2025
  • 2024
  • 2023
  • 2022
  • 2021
  • 2020
  • 2019
  • 2018
  • 2017
  • 2016
  • 2015
  • 2014
  • 2013
  • 2012
  • 2011
  • 2010

New method to discover protease and other hydrolase substrates in live mammalian cells

Using genetic code expansion techniques, Jason Chin’s group in the LMB’s PNAC Division have designed a new mechanism-based, light-activated technique to trap and identify new protease and other hydrolase substrates.

More…

Published on 17th February, 2022

Cryptochrome proteins are integral to maintain time within the brain’s master clock

Schematic using confocal microscopy (upper images) shows the localisation of fluorescently-tagged, endogenous PER2 (green), present in the nuclei of SCN neurons (blue). In the absence of CRY proteins, PER2 was instead localised predominantly within the cytoplasm and exhibited greater overall intracellular mobility (middle schematic), with absence of rhythmicity in SCN brain slices (lower schematic). Resuming CRY expression to a critical threshold only partially relocalised PER2 protein to the nucleus, yet was sufficient to fully restore rhythmicity to SCN brain slices (right most panels).

Using synthetic biological techniques, Michael Hastings’ group have collaborated with Jason Chin to gain novel insights into the molecular and cellular processes which govern the suprachiasmatic nucleus, and identified a key regulatory role of cryptochrome clock proteins.

More…

Published on 20th January, 2022

Atomic structures of Aβ42 filaments from the brains of individuals with Alzheimer’s disease and other neurodegenerative conditions

Atomic structure for Type I (Left) and Type II (Right) of amyloid-β 42 filaments

Collaboration between Sjors Scheres’ (Structural Studies), Benjamin Ryskeldi-Falcon’s and Michel Goedert’s (both Neurobiology) groups have used cryo-EM to reveal structures of Aβ42 filaments, the key factor behind the pathogenesis of Alzheimer’s disease.

More…

Published on 14th January, 2022

Structural breakthrough in study of aggregated TDP-43 protein in brains of ALS and FTD sufferers

The conserved structure of pathological TDP-43 filaments from amyotrophic lateral sclerosis with frontotemporal lobar degeneration determined by electron cryo-microscopy.

Cryo-EM analysis of TDP-43 filaments by Benjamin Ryskeldi-Falcon’s group in the LMB’s Neurobiology Division has revealed the atomic structure of the characterising feature of neurodegenerative diseases ALS and FTD.

More…

Published on 8th December, 2021

How DNA damage induces appetite suppression and weight loss

Model outlining how formaldehyde can damage the proximal tubules and trigger release of the anorexic hormone GDF15 which results in food aversion, presumably to reduce the burden of ingested toxins. Inset, model of the molecular mechanism by which ADH5 and CSB cooperate to protect cells from formaldehyde damage, which is sensed by the stalled transcription machinery and can trigger p53 dependent activation of GDF15.

DNA damage caused by formaldehyde is repaired involving CSA and CSB genes. KJ Patel’s lab have shown how, when this pathway is mutated such as in people with Cockayne syndrome, the appetite suppression hormone GDF15 is released leading to severe weight loss.

More…

Published on 24th November, 2021

Early transcriptional patterning of a forming tissue is essential to morphogenesis of a tubular organ

Time-lapse quantitative study of developing salivary glands in Drosophila embryos, conducted by Katja Röper’s group, reveals the key control factors behind cells’ behavioural transitions that are essential for correct organ formation.

More…

Published on 8th November, 2021
  • «
  • ‹
  • 12
  • 13
  • 14
  • 15
  • 16
  • ›
  • »

Primary Sidebar

News & Events

  • Insight on Research
  • LMB News
  • LMB In The News
  • LMB Alumni News
  • Public Engagement
    • Supporting Education
      • I’m a scientist, get me out of here!
      • London International Youth Science Forum
    • LMB on the Road
      • Cambridge Festival
      • Royal Society Summer Science Exhibitions
      • Big Biology Day
      • LifeLab
    • Events at the LMB
      • Artists in Residence: Home in the Service of Science
      • LMB Open Day 2017
      • STEM in Song
    • Resources
      • Image Game
    • LMB Science Stories
      • Electron Cryo-microscopy
      • Tau and Alzheimer’s
    • Past Events
      • MRC Festival of Research
      • Crystal Growing Competition
        • Past Winners
        • MRC Lab Visits
      • The WormWatch Lab
    • Contact Us
  • Scientific Seminars
    • LMB Named Lectures
  • LMB Exhibitions
    • Sample holders for electron cryomicroscopy
    • Humira
    • Curios of 60 years of the LMB
  • Scientific Training
  • Information for Journalists
  • Scientific Glossary
  • Photographs
  • LMB 365
  • Newspaper Archive

Search

  • Privacy & Cookies
  • Contact Directory
  • Freedom of Information
  • Site Map
Find Us
©2025 MRC Laboratory of Molecular Biology,
Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK. 01223 267000

The MRC is part of UK Research and Innovation

Contact Us

This site uses cookies. The LMB may use cookies to analyse how you use our website. We use external analysis systems which may set additional cookies to perform their analysis. These cookies (and any others in use) are detailed in our Privacy and Cookies Policy and are integral to our website. You can delete or disable these cookies in your web browser if you wish, but then our site may not work as it is designed. Ok