MRC Laboratory of Molecular Biology
One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health.
Menna Clatworthy’s group has identified a key signalling molecule in determining the balance between wound healing and defence against bacterial invasion, with implications for our understanding of the immune system’s role in inflammatory bowel disease.
Our daily cycle is controlled by a central clock known as the SCN, but it has been unclear how the network of cells that make up the SCN generate the properties that make it a strong clock. Michael Hastings’ group has identified a signalling axis that acts as a pacemaking hub.
Understanding minute structural differences in (G protein-coupled receptor) GPCR complexes could lead to the design of more efficacious drugs that have fewer side effects
Septic shock is a common cause of death that can be triggered by LPS, a component of the outer membrane of some bacteria. Felix Randow’s group has shown how the immune response against cytosol-invading bacteria is activated by a signalling platform built on their surface.
The human brain is bathed in a supportive fluid called the cerebrospinal fluid (CSF) that provides various nutrients. Madeline Lancaster’s group have now developed a new brain organoid that produces CSF and has the potential to predict whether drugs can access the brain.
New research suggests that DNA building blocks may have coexisted with RNA at the dawn of life