Using a combination of light microscopy and biochemical assays, Harvey McMahon’s group, in the LMB’s Neurobiology Division, have identified aggregation-dependent endocytosis (ADE) as the pathway by which cells respond to surface perturbations.
Aggregation of proteins on cell surface triggers rapid uptake and degradation
New computational method for genome analysis
Julian Gough’s group, in the LMB’s Structural Studies Division, has designed a computational method for genome analysis capable of making knowledge-based predictions directly from a human genome.
HIV-1 needs the cell metabolite IP6 to build its capsid and infect cells
In an international collaboration led by Leo James’ group, researchers have discovered that HIV-1 builds its capsid using a metabolite called IP6 that it captures from cells with a net-like protein lattice. Disabling this capture mechanism prevents capsid construction and renders HIV-1 non-infectious.