Greg Jefferis’ group in the LMB’s Neurobiology Division, in collaboration with scientists at the Janelia Research Campus, have predicted the sign of each synapsis in the fruit fly brain.
First map of the neurotransmitters used in the fruit fly brain
ModelAngelo software expands cryo-EM toolkit with faster atomic model building and identification of novel proteins
Kiarash Jamali, a Ph.D. student in Sjors Scheres’ group in the LMB’s Structural Studies Division, has designed a new machine learning software capable of fast, accurate model building at atomic levels and identification of new proteins beyond previous capabilities.
Structure of γ-Tubulin Ring Complex provides insights into nucleation process behind microtubule formation
David Barford’s group, in the LMB’s Structural Studies Division, in collaboration with John Kilmartin in the LMB’s Cell Biology Division, have used electron cryo-tomography and sub-tomogram averaging to determine the structure of native γTuRC capping microtubules from extracted Spindle Pole Bodies.
New 3D embryonic stem cell culture system sheds light on gastrulation mechanism
Marta Shahbazi’s group in the LMB’s Cell Biology Division has developed a three-dimensional embryonic stem cell culture system to study the molecular motivations behind basal delamination where cells change shape and move from their tissue of origin.
A genome-wide resource for dissecting transport within cells
Chun Hao Wong and Simon Bullock, from the LMB’s Cell Biology Division, together with Douglas Ross-Thriepland and colleagues at AstraZeneca, have systematically disrupted every gene in cultured human cells to reveal a large number of new factors required for organisation of cells by the microtubule motor dynein.
New insights into genetic mechanisms involved in kidney development
John-Poul Ng-Blichfeldt and Katja Röper, in the LMB’s Cell Biology Division, have collaborated with Julie Williams from AstraZeneca, to use renal organoids to investigate the human mesenchymal-to-epithelial transition, crucial to the morphogenesis of kidneys.