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MRC Laboratory of Molecular Biology

MRC Laboratory of Molecular Biology

One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health.

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Insight on Research

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New insights into genetic mechanisms involved in kidney development

John-Poul Ng-Blichfeldt and Katja Röper, in the LMB’s Cell Biology Division, have collaborated with Julie Williams from AstraZeneca, to use renal organoids to investigate the human mesenchymal-to-epithelial transition, crucial to the morphogenesis of kidneys.

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Published on 9th February, 2024

Phosphatase study solves substrate recruitment puzzle

Anne Bertolotti’s group in the LMB Neurobiology Division have revealed the substrate recruitment mechanism of major phosphatase non-catalytic subunit, PPP1R15B, by using full-length eIF2 and a combination of approaches.

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Published on 1st February, 2024

Alzheimer’s disease and chronic traumatic encephalopathy tau filament assembly intermediates revealed by cryo-EM

Time-resolved study of in vitro assembly of truncated tau by the groups of Sjors Scheres and Michel Goedert, from the LMB’s Structural Studies and Neurobiology Divisions, identifies formation of many different disease-specific intermediate amyloid filaments.

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Published on 4th January, 2024

Molecular mechanics of mitotic error correction revealed by cryo-EM

Graphic illustrating structure of yeast outer kinetochore – microtubule complex: the grey microtubule is encircled by the multicoloured outer kinetochore ring structure composed of Ndc80-Nuf2 and Dam1c ring complexes.

Structure of the outer kinetochore bound to microtubules, determined by David Barford’s group in the Structural Studies Division, reveals how phosphorylation regulates mitotic spindle chromosome attachment errors to ensure DNA is equally segregated into two daughter cells.

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Published on 8th December, 2023

Discovery of a new amyloid-forming protein in neurodegenerative disease

Cryo-EM structure of TAF15 and brain.

The discovery of TAF15 amyloid filaments in patients with frontotemporal lobar degeneration by the group of Benjamin Ryskeldi-Falcon in the LMB’s Neurobiology Division establishes this protein as a diagnostic and therapeutic target for this neurodegenerative disorder.

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Published on 6th December, 2023

Low energy cryo-EM to widen accessibility for fast and accurate structure determination

A collaborative team lead by Chris Russo’s group in the LMB’s Structural Studies Division has developed a new electron cryo-microscope, capable of solving atomic structures at a fraction of the energy and cost of existing models.

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Published on 28th November, 2023
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