MRC Laboratory of Molecular Biology
One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health.
Sjors Scheres, LMB group leader, awarded the Royal Netherlands Chemical Society Gold Medal. The KNCV Gold Medal is the highest Dutch award for Chemistry. The award honours Sjors’s major contribution to electron microscopy and structural chemistry, in particular his work in the field of cryo-EM. More…
John Sulston is best known for the leading role he played in the Human Genome Project. But earlier in his career, while working at the LMB, he studied the development of the nematode worm. Sarah Harrop tells the story behind a lab notebook entry which contributed to a Nobel Prize-winning breakthrough. More...
“Move over X-ray crystallography. Electron cryo-microscopy is kicking up a storm by revealing the hidden machinery of the cell” – this Nature News Feature highlights the work of the LMB’s Richard Henderson, Nigel Unwin and Sjors Scheres in developing cryo-EM techniques that are changing the way scientists solve molecular structures. More…
Madeline Lancaster’s method of growing organoids to understand early brain development is featured in this “guide to crafting tissues in a dish that reprise in vivo organs” More…
The wriggling and writhing of worms may hold clues to the inner workings of our brains, according to scientists at the MRC’s Clinical Sciences Centre and their collaborators at the LMB. The researchers have developed a pioneering tool to analyse a worm’s posture as it wriggles, and will use the tool to investigate how exactly the worm’s brain controls its movements. More …
Abstract: They started out as a useful tool for studying the immune system in the lab and now they’re a family of drugs treating millions of patients, with global revenues of nearly $75 billion in 2013. MRC funding and researchers have been entwined with the monoclonal antibodies story from the very beginning. Forty years ago this month, Nature published a paper by the LMB’s César Milstein and Georges Köhler which described how they’d made mouse monoclonal antibodies. Here we look at the landmarks on the 40-year journey. More…