LMB In The News

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Worming our way to a new understanding of behaviour

MRC Clinical Science Centre

The wriggling and writhing of worms may hold clues to the inner workings of our brains, according to scientists at the MRC’s Clinical Sciences Centre and their collaborators at the LMB. The researchers have developed a pioneering tool to analyse a worm’s posture as it wriggles, and will use the tool to investigate how exactly the worm’s brain controls its movements. More


From tool to therapy: a timeline of monoclonal antibody technology


Abstract: They started out as a useful tool for studying the immune system in the lab and now they’re a family of drugs treating millions of patients, with global revenues of nearly $75 billion in 2013. MRC funding and researchers have been entwined with the monoclonal antibodies story from the very beginning. Forty years ago this month, Nature published a paper by the LMB’s César Milstein and Georges Köhler which described how they’d made mouse monoclonal antibodies. Here we look at the landmarks on the 40-year journey. More…


The MORPHEUS II protein crystallization screen


Fabrice Gorrec from the LMB has published developments related to MORPHEUS II – a protein crystallization screen. He has demonstrated that additives selected from the PDB that are under-represented in traditional screens can be combined to formulate suitable and useful conditions, not only for crystallization but the overall structure determination process. More


New details of the transmission of stimuli in living organisms unveiled


A team lead by Dmitry Veprintsev from the Paul Scherrer Institute (PSI) and ETH Zurich together with Madan Babu Mohan’s group at LMB and the pharmaceutical company Roche provide new details of how the activation of G-protein-coupled receptors takes place and demonstrate that only a few amino acids have a major influence on GPCR function. More…


Monoclonal antibodies: the invisible allies that changed the face of medicine


They are tiny magic bullets that are quietly shaping the lives of millions of patients around the world. Monoclonal antibodies are contained in six out of ten of the world’s bestselling drugs, helping to treat everything from cancer to heart disease to asthma. The technique for producing them was first published 40 years ago by César Milstein and Georges Köhler, at the LMB. More…


The origin of biological clocks

Science News

Review of research, including that of the LMB’s John O’Neill, on the evolutionary story of circadian rhythms. More…


Harnessing computer power to understand biology


In an interview for Science Careers, former LMB Group Leader Sarah Teichmann talks about how she was inspired by computational biology by Cyrus Chothia, with whom she did her PhD. She also shares how she gained her skills and abilities and what doors they opened to her. More…


How to grow a brain

MRC Logo

Being able to grow rudimentary brain tissue in the lab means that researchers can study organ development and disease. But how do you go from stem cells to a ‘mini-brain’? New LMB group leader Madelaine Lancaster’s research is highlighted in a report by the Long+Short magazine’s Ben Martynoga on the latest MRC Insight blog. More…


Reviewing translation at the MRC

MRC Technology

Work by LMB’s Mike Gait, Jason Chin and Satpal Virdee, and Fabrice Gorrec highlighted in a MRC Review of recent successes in translational research. More…


Cambridge Neuroscience 2015 Seminar at the LMB: Brain Chat podcast

Cambridge Neuroscience

Brain Chat – a podcast answering key questions about brain and behaviour, with Hannah Critchlow reporting on exciting brain research revolutions presented at the Cambridge Neuroscience 2015 Seminar held at LMB. More…