LMB In The News


Antibodies co-opt anti-microbial response to clear intraneuronal tau

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Leo James and Michel Goedert, group leaders at the LMB, recently published work in PNAS providing an explanation for how therapeutic antibodies eliminate pathogenic forms of tau protein. Here, Alzforum explore the background, results and implications of this study. More…

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Dementia – how close are we to having effective treatments?

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Cambridge Neuroscience, of which the LMB is a part, plays a key role in coordinating dementia research across the large and diverse community of neuroscientists in Cambridge, helping scientists and clinicians work together. The organisation has produced a new film describing some of the progress now being made against this devastating disease, including commentary from Michel Goedert, group leader in the LMB’s Neurobiology Division, who discovered how tau fibres twist together to form tangles, a hallmark of Alzheimer’s, a type of dementia. More…

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A chain of events

Linear ubiquitin chains whose very existence once was debated, now are known to play a critical role in an inflammatory disease, thanks to the discovery of an enzyme. David Komander’s group from the LMB are amongst a group of scientists researching the enzymes of the ubiquitin system, which has already shown how mutations in the gene for OTULIN, an enzyme belonging to the OTU family of deubiquitinases, cause a rare systemic inflammatory disease. More…

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Cell scientist to watch – Madeline Lancaster

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Madeline Lancaster, group leader in the LMB’s Cell Biology Division, is interviewed by the Journal of Cell Science and describes her impetus to pursue a career in science, discusses starting her own lab at the LMB and talks about her current research. More…

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HIV Research Breakthroughs 2016

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Medical Daily includes work by the LMB’s Leo James’s group and University College London on improving antiviral drugs as one of its HIV research breakthroughs of 2016. More…

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New microscope lens: top ten breakthroughs

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Work by MRC funded Gail McConnell and LMB Emeritus, Brad Amos and colleagues at the University of Strathclyde have been selected for Physics World’s Top Ten Breakthroughs of 2016, for creating a new microscope lens that offers the unique combination of a large field of view with high resolution. Called a mesolens, the device allows a confocal microscope to create 3D images of much larger biological samples than was previously possible – while providing detail at the sub-cellular level. The development of the lens was initiated by Brad Amos at the LMB. More…

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Richard Pannell “wins science ‘Oscar’ for his life’s work”

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The Haverhill Echo celebrates local resident Richard Pannell’s MRC Lifetime Achievement CEO Award. Richard, who was nominated by his current supervisor, Andrew McKenzie, has worked at the LMB since 1980. More…

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Master of Trinity’s Bicycle worth up to $1 billion

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Bicycle Therapeutics, the Cambridge biotech company, has done a collaboration deal with AstraZeneca which puts it in line for up to $1 billion. Bicycle Therapeutics’ unique intellectual property is based on the work initiated at the MRC Laboratory of Molecular Biology in Cambridge by the scientific founders of the company, Sir Gregory Winter (Master of Trinity College, Cambridge) and Prof Christian Heinis. Bicycle is pioneering a new class of drugs based on its bicyclic peptide platform, and will be working with AZ to spot and develop new treatments for respiratory, cardiovascular and metabolic diseases. More…

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Richard Henderson wins prize at Carlsberg’s ‘Science to Business’ Forum

Richard Henderson, group leader at the LMB, has been awarded the Kaj Linderstrøm Lang Prize at Carlsberg’s ‘Science to Business’ Forum in recognition of his pioneering work towards obtaining high resolution atomic structures of membrane proteins and membrane protein complexes by cryo electron microscopy. More…

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Scientists are battling a drug-resistant pathogen which could prove fatal to patients with cystic fibrosis

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Andres Floto, group leader in the University of Cambridge Research Unit based in the LMB, talks to Cambridge TV about his discovery that multidrug resistant mycobacterial infections, which can be fatal for cystic fibrosis patients, can be transferred from patient to patient, and how this new insight has impacted the design of the cystic fibrosis clinic in the new Papworth Hospital. More…

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