LMB In The News

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ISCB Senior Scientist Award for Cyrus Chothia

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A look at the career of LMB’s Cyrus Chothia and his work on the structures and functions of proteins, following announcement of his ISCB Senior scientist award. More…

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New Approach To Control Enzyme Function In Cells

Chemical & Engineering News

A new technique, devised by Jason Chin’s group, could make it easier to target and inhibit specific enzymes and other proteins in cells and to turn that regulation on and off at will with light. Bioorthogonal ligand tethering, or BOLT, has been used to create an inhibitor that can regulate the activity of a target enzyme selectively, an approach called iBOLT. More…

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A new genetic switch uncovered in the long genes expressed in our brain

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Jernej Ule, former LMB group leader, and Vincent Plagnol from UCL have discovered a new mechanism for ‘splicing-based’ gene regulation, with possible implications for brain-related disorders. Jernej began this research when he was in the LMB’s Structural Studies Division. More…

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Did frosts lead to life on Earth?

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Large RNA molecules can be assembled from basic biochemical building blocks during cycles of freezing and thawing. This breakthrough from Philipp Holliger’s group at the LMB reinforces the possibility that RNA was responsible for both molecular heredity and metabolism in primordial biochemistry. More…

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Making Sense of the Chemistry That Led to Life on Earth

New York Times

An article in the New York Times highlights the work of John Sutherland, a group leader at the LMB, who has determined a possible chemical pathway to produce the starting materials of life. In his laboratory he tested all the chemical reactions needed to make precursors of lipids, nucleotides and amino acids, the building blocks of life, and developed evidence that these could occur under the conditions expected of primitive Earth. More…

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Towards preventing neurodegenerative diseases

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Research led by the LMB’s Anne Bertolotti has discovered a selective inhibitor of a phosphatase enzyme that could prevent protein misfolding diseases. The scientists showed that the new molecule, dubbed Sephin1, countered the effects of aggregating proteins in mouse models of amyotrophic lateral sclerosis and Charcot-Marie-Tooth disease, and might do so for other neurodegenerative disorders. More…

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Mechanism-based therapeutics of common human neurodegenerative diseases

University Of Cambridge

The LMB and the Department of Clinical Neurosciences have announced an initiative in mechanism-based therapeutics of common human neurodegenerative diseases. This initiative, developed by Michel Goedert and Alastair Compston, aims to identify core mechanisms of protein aggregation and spreading in neurodegeneration, and to apply that knowledge to study putative new therapies. More…

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First pictures of the mitoribosome taken

Chemical & Engineering News

Researchers, including a team from the LMB, have obtained structures of complete ribosomes from mammalian mitochondria at near-atomic resolution for the first time. More…

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Body clock expert talks to students

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Michael Hastings delivers sixth form lecture at King William’s College, Isle of Man, on his research into circadian rhythms and biological clocks. More…

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Image of the Week: Structure of the dynactin complex

Wellcome Trust

The structure of the dynactin complex, solved by Andrew Carter’s group at the LMB, is the cover story on this week’s Science and is the Wellcome Trust’s Image of the week. The picture shows a model of the dynein/dynactin protein machine that moves cargo around the cell, that was determined using electron cryo-microscopy. More…

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