![Cryo-EM maps of multiple system atrophy Type I (left) and Type II (right) α-synuclein filaments with overlaid atomic models](https://www2.mrc-lmb.cam.ac.uk/wordpress/wp-content/uploads/MSA_Figure_2_sq-150x150.jpg)
Abnormal filaments of α-synuclein define several neurodegenerative diseases, including multiple system atrophy (MSA) and Parkinson’s disease. Michel Goedert’s and Sjors Scheres’ groups have now determined the first structures of α-synuclein filaments from human brain.