MRC Laboratory of Molecular Biology
One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health.
Use of reverse transcription for synthesis of xeno-nucleic acids is limited by low reverse transcriptase enzyme activity. Philipp Holliger’s group have developed a new directed evolution method to improve reverse transcriptase activity for any nucleic acid chemistry.
Multiple ribosomes speed along an mRNA to translate the genetic code into proteins. Szymon Juszkiewicz and Manu Hegde now find that when ribosomes collide, cells stop new ribosomes from starting translation and recruit a factor that clears the collision.
Each of our cells contains about two metres of DNA. To be able to store all of this, the DNA must be very tightly compacted. Jan Löwe’s group have produced the first atomic model of condensin, a complex known to have a role in compacting DNA into chromosomes, in its entirety.
Menna Clatworthy’s group has identified a key signalling molecule in determining the balance between wound healing and defence against bacterial invasion, with implications for our understanding of the immune system’s role in inflammatory bowel disease.
Our daily cycle is controlled by a central clock known as the SCN, but it has been unclear how the network of cells that make up the SCN generate the properties that make it a strong clock. Michael Hastings’ group has identified a signalling axis that acts as a pacemaking hub.
Understanding minute structural differences in (G protein-coupled receptor) GPCR complexes could lead to the design of more efficacious drugs that have fewer side effects