New research suggests that DNA building blocks may have coexisted with RNA at the dawn of life
Primitive genetic alphabet based on RNA and DNA
First structures of α-synuclein filaments from human brain
Abnormal filaments of α-synuclein define several neurodegenerative diseases, including multiple system atrophy (MSA) and Parkinson’s disease. Michel Goedert’s and Sjors Scheres’ groups have now determined the first structures of α-synuclein filaments from human brain.
Tracing a transcription initiation factor’s molecular journey across evolutionary timescale
Unravelling the replisome: how a molecular machine overcomes obstacles to DNA replication
Every time a cell divides, all of its genetic material must be accurately duplicated. This process is controlled by a molecular machine known as the replisome. Joseph Yeeles’ group has now produced the highest resolution, and most complete, structure of a replisome to date.
Ankyrins: a missing molecular link in mechanical senses
Hearing and touch depend on the ability of sensory neurons to be activated by a force, such as pressure or vibration from sound, and then pass information on to the brain. William Schafer’s group has identified some of the key proteins that make this possible.
How alcohol-derived DNA damage is fixed
Alcohol consumption can indirectly cause damage to our DNA and elevate cancer risk. KJ Patel’s group in the LMB’s PNAC Division has identified a novel repair mechanism for DNA damage created by by-products of alcohol metabolism.