Introduction of ultrasound machines has allowed LMB animal technicians to accurately detect pregnancy in mice as early as 5.5 days, which ultimately reduces the number of mice needed for research.
Using ultrasound to determine pregnancy in mice
New potential therapy for neurodegeneration removes tau aggregates and improves motor function
Leo James’ group, in the LMB’s PNAC Division, have worked with Will McEwan’s group at the UK Dementia Research Institute to design two new therapeutics which harnesses cellular machinery to remove tau aggregates, improving motor skills in mice affected by neurodegenerative disease.
Unprecedented heteromeric amyloid structure in neurodegenerative disease
Surprising advance to our understanding of neurodegenerative diseases, as Diana Arseni and Benjamin Ryskeldi-Falcon in the LMB’s Neurobiology Division find that frontotemporal lobar degeneration Type C filaments include both annexin A11 and TDP-43 in a unique heteromeric structure.
How cells enter the germline at the right time and place during embryonic development
Marta Shahbazi’s group in the LMB’s Cell Biology Division has determined that contact with extracellular matrix proteins prevents embryonic cells from becoming germ cells.
How protons tune AMPA receptor-mediated information processing at neuronal synapses
Ingo Greger’s group, in the LMB’s Neurobiology Division, find that low pH causes protonation of histidine 208 embedded within GluA2 NTDs – a mechanism which has potential to tune strength of synaptic transmission and plasticity, key to learning and memory.
Key role for Leukaemia inhibitory factor in systemic immunity
Led by Mayuri Gogoi, Andrew McKenzie’s group in the LMB’s PNAC Division have determined that the cytokine LIF production by type-2 innate lymphoid cells dictates the movement of immune cells from the site of lung infection or chronic allergic reaction, thereby regulating tissue localised versus systemic immunity.