Marta Shahbazi’s group in the LMB’s Cell Biology Division has determined that contact with extracellular matrix proteins prevents embryonic cells from becoming germ cells.
How cells enter the germline at the right time and place during embryonic development
How protons tune AMPA receptor-mediated information processing at neuronal synapses
Ingo Greger’s group, in the LMB’s Neurobiology Division, find that low pH causes protonation of histidine 208 embedded within GluA2 NTDs – a mechanism which has potential to tune strength of synaptic transmission and plasticity, key to learning and memory.
Key role for Leukaemia inhibitory factor in systemic immunity
Led by Mayuri Gogoi, Andrew McKenzie’s group in the LMB’s PNAC Division have determined that the cytokine LIF production by type-2 innate lymphoid cells dictates the movement of immune cells from the site of lung infection or chronic allergic reaction, thereby regulating tissue localised versus systemic immunity.
Combining single molecule-imaging and cryo-EM resolves DNA repair mystery
Lori Passmore’s group in the LMB’s Structural Studies Division have identified the molecular mechanism by which the FANCD2-FANCI protein complex, which acts as a travelling DNA clamp, is able to identify sites of DNA strand damage and mark them for repair.
Motion detector in the brain translates visual information into movement
Marco Tripodi’s group, in the LMB’s Neurobiology Division, reveals how visual information is progressively channelled to motor neurons.
Transcription factor Mef2d is crucial to the function of type-2 innate lymphoid cells during allergic responses
Andrew McKenzie’s group, in the LMB’s PNAC Division, have applied a new screening system and synthetic Boolean logic gate circuits to offer unprecedented insights into the molecular regulation of type-2 innate lymphoid cells, a key contributor to allergic responses.