![Embryo salivary gland development](https://www2.mrc-lmb.cam.ac.uk/wordpress/wp-content/uploads/ExpID0141-ScribGFP-embryo01_all_denoised_imaris_2018-07-24T14-36-22.220-2-150x150.jpg)
Many complex tubular organs, including kidney, lung, the intestine and several glands, form from a flat layer of cells during animal development. Failure of proper tube formation underlies severe congenital malformations such as Spina Bifida, and the failure to maintain tube architecture for instance underlies Polycystic Kidney Diseases. How tissues transition from flat 2D structures to 3D tubes is poorly understood.