MRC Laboratory of Molecular Biology
One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health.
Ingo Greger’s group, in the LMB’s Neurobiology Division, find that low pH causes protonation of histidine 208 embedded within GluA2 NTDs – a mechanism which has potential to tune strength of synaptic transmission and plasticity, key to learning and memory.
Led by Mayuri Gogoi, Andrew McKenzie’s group in the LMB’s PNAC Division have determined that the cytokine LIF production by type-2 innate lymphoid cells dictates the movement of immune cells from the site of lung infection or chronic allergic reaction, thereby regulating tissue localised versus systemic immunity.
Lori Passmore’s group in the LMB’s Structural Studies Division have identified the molecular mechanism by which the FANCD2-FANCI protein complex, which acts as a travelling DNA clamp, is able to identify sites of DNA strand damage and mark them for repair.
Marco Tripodi’s group, in the LMB’s Neurobiology Division, reveals how visual information is progressively channelled to motor neurons.
Andrew McKenzie’s group, in the LMB’s PNAC Division, have applied a new screening system and synthetic Boolean logic gate circuits to offer unprecedented insights into the molecular regulation of type-2 innate lymphoid cells, a key contributor to allergic responses.
Tanmay Bharat’s group, in the LMB’s Structural Studies Division, reveals the surface layer structure of the archaeon Nitrosopumilus maritimus, crucial to the global nitrogen cycle.