MRC Laboratory of Molecular Biology
One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health.
Time-resolved study of in vitro assembly of truncated tau by the groups of Sjors Scheres and Michel Goedert, from the LMB’s Structural Studies and Neurobiology Divisions, identifies formation of many different disease-specific intermediate amyloid filaments.
Structure of the outer kinetochore bound to microtubules, determined by David Barford’s group in the Structural Studies Division, reveals how phosphorylation regulates mitotic spindle chromosome attachment errors to ensure DNA is equally segregated into two daughter cells.
The discovery of TAF15 amyloid filaments in patients with frontotemporal lobar degeneration by the group of Benjamin Ryskeldi-Falcon in the LMB’s Neurobiology Division establishes this protein as a diagnostic and therapeutic target for this neurodegenerative disorder.
A collaborative team lead by Chris Russo’s group in the LMB’s Structural Studies Division has developed a new electron cryo-microscope, capable of solving atomic structures at a fraction of the energy and cost of existing models.
The entire wireless neuropeptide signalling network of a whole animal, the nematode worm C. elegans, has been mapped for the first time by William Schafer’s group in the LMB’s Neurobiology Division and collaborators.
A collaboration between the groups of Emmanuel Derivery, and John O’Neill in the LMB’s Cell Biology Division, and Rachel Edgar’s group at Imperial College London, have discovered a rapid mechanism by which cells ensure that an optimal balance of water is available for biochemical reactions and protein structure and function.