MRC Laboratory of Molecular Biology
One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health.
A collaborative study including researchers in Leo James’ group in the LMB’s PNAC Division and Bicycle Therapeutics has developed a new class of antivirals which can be combined together like building blocks to effectively immobilise COVID-19’s Spike protein and block infection.
Using high-throughput CRISPR screening, researchers in Andrew McKenzie’s group in the LMB’s PNAC Division have identified a previously unknown immune-related role for ADNP and identified the molecular mechanism by which it regulates IL-13 expression in allergic immune responses.
Researchers from Greg Jefferis’ group in the LMB’s Neurobiology Division have determined the highly specified neural mechanisms which allow Drosophila flies to identify and locate males by scent of a pheromone.
New pre-clinical research in Roger Williams’ group at MRC LMB, University College London and AstraZeneca discovers an activator of PI3Ka that can protect heart cells from dying in the case of injury and accelerate the regeneration of neurons
Leo James’ group, in the LMB’s PNAC Division, has identified surprising protein modifications that underly Trim-Away protein degradation technology, which may explain its broad applicability to degrade almost any cellular protein.
Using electron microscopy, Tanmay Bharat’s group reveals the surface layer structure of the extremophilic bacterium, Deinococcus radiodurans.