Philipp Holliger and Ben Porebski in the LMB’s PNAC Division, in collaboration with AstraZeneca, have developed a new ultra-high-throughput method that shows promise to accelerate antibody discovery for a wide range of targets.
New deep screening technique enables rapid discovery of high-affinity antibodies to clinically relevant drug targets
New method to untangle the contribution of signalling pathways involved in asymmetric cell division
Emmanuel Derivery’s group, in the LMB’s Cell Biology Division, has developed a method to directly untangle the contribution of any signalling pathway involved in asymmetric cell division.
First Cryo-EM structures of homomeric GluA1 AMPA glutamate receptor reveals functional roles for N-terminal domains
Electron cryo-microscopy structures of GluA1 AMPA receptors from Ingo Greger’s group in the LMB’s Neurobiology Division reveals that previously unseen structural flexibility of N-terminal domains is crucial for regulating the open-close speed of ion channel gates and recruiting the receptor into synapses.
Activation of the integrated stress response by inhibitors of its kinases
New research from Anne Bertolotti’s group in the LMB’s Neurobiology Division reveals that nanomolar ATP-competitive inhibitors of integrated stress response (ISR) kinases unexpectedly activate the ISR at micromolar concentrations by directly binding to and activating a sister ISR kinase.
Cryo-EM structures reveal the unexpected ability of shelterin to modulate telomeric nucleosomes
Kelly Nguyen’s group, in the LMB’s Structural Studies Division, have solved the cryo-EM structures of a telomeric nucleosome both bound and unbound to shelterin component TRF1, providing novel insights into the molecular interactions between shelterin and nucleosomes.
Repurposed DNA repair factors prevent expansions of ‘parasitic’ genomic retrotransposons
Nazareno Bona and Gerry Crossan, in the LMB’s PNAC Division, present a mechanistic explanation of how Fanconi anaemia factors act in a common pathway to restrict LINE-1 retrotransposition.