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MRC Laboratory of Molecular Biology

MRC Laboratory of Molecular Biology

One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health.

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Insight on Research

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Cryo-EM structures reveal the unexpected ability of shelterin to modulate telomeric nucleosomes

Kelly Nguyen’s group, in the LMB’s Structural Studies Division, have solved the cryo-EM structures of a telomeric nucleosome both bound and unbound to shelterin component TRF1, providing novel insights into the molecular interactions between shelterin and nucleosomes.

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Published on 29th August, 2023

Repurposed DNA repair factors prevent expansions of ‘parasitic’ genomic retrotransposons

Nazareno Bona and Gerry Crossan, in the LMB’s PNAC Division, present a mechanistic explanation of how Fanconi anaemia factors act in a common pathway to restrict LINE-1 retrotransposition.

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Published on 14th August, 2023

A database to identify important genes of unknown function for analysis

Sean Munro’s group in the LMB’s Cell Biology Division have investigated the potential biological significance of conserved genes of unknown function by developing an Unknome database to systematically analyse their identification and characterisation.

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Published on 9th August, 2023

TDP-43 forms amyloid filaments with distinct folds in different neurodegenerative conditions

Cryo-EM structures from the most common type of frontotemporal lobar degeneration, determined by Benjamin Ryskeldi-Falcon’s group in the LMB’s Neurobiology Division, reveals that TDP-43 forms amyloid filaments with distinct folds in different neurodegenerative conditions.

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Published on 2nd August, 2023

New insights into how DNA synthesis is started during the process of chromosome replication

By determining cryo-EM structures of budding yeast and human replisomes Joseph Yeeles group in the LMB’s PNAC Division reveal a conserved mechanism for the coordination of nascent-strand priming.

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Published on 27th July, 2023

Keeping protein subunits in check via assembly quality control 

Graphic illustrating how chaperonin subunits that fail to assemble, either because they are orphan subunits or because assembly if incomplete, are routed for degradation by the ubiquitin ligase HERC2 and adapter ZNRD2.

Cells eliminate “orphan” proteins that have failed to assemble into the molecular machines within which they normally function. Manu Hegde’s group have now elucidated the mechanism by which one type of orphan is selectively recognised and tagged for destruction.

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Published on 21st July, 2023
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