Suyang Zhang’s group, in the LMB’s Structural Studies Division, has elucidated how the DNA helicase RECQL5 works with the transcription-coupled DNA repair complex to brake and accelerate RNA polymerase II transcription to maintain genome stability.
How RECQL5 applies the brakes to speeding RNA polymerase II to safeguard genome stability
Architecture of the disease-prone GluA3 receptor unlocks new avenues for drug design
Ingo Greger’s group, in the LMB’s Neurobiology Division, discover that the GluA3 AMPAR adopts a structural organization that substantially diverges from all the other AMPA receptors.
Dual biological clocks discovered in intertidal crustaceans
Collaborative study between Michael Hastings’s group in the LMB’s Neurobiology Division and David Wilcockson at Aberystwyth University reveals that crustaceans have two distinct cerebral clocks – one to track days and one for tides – which operate in parallel using overlapping genetic components.
Uncovering the hidden complexity behind the brain’s master clock
Study of body clock proteins led by Nicola Smyllie in Michael Hastings’s group in the LMB’s Neurobiology Division, reveals that PER and CRY, key body clock proteins, act more independently than previously thought, challenging long-held understanding of our body’s circadian rhythms.
A colder frontier: cryo-EM at liquid helium temperatures
New specimen supports, designed by Chris Russo’s group in the LMB’s Structural Studies Division, solve decades-long question on how to use liquid helium in cryo-EM to reduce radiation damage and improve information capture.
Cytosol-adapted bacterium usurps host defence mechanism to evade LPS ubiquitylation
Felix Randow’s group, in the LMB’s PNAC Division, has identified the mechanism by which cytosol-dwelling Shigella flexneri bacteria use their effector protein IpaH1.4 to avoid LPS ubiquitylation by degrading the host E3 ligase RNF213.