Multidisciplinary study from Ingo Greger’s group in the LMB’s Neurobiology Division reveals the structures and subunit assembly of GluA4 AMPA receptors in the mammalian cerebellum that support cell-type specific functions.
Distinct AMPA receptor sub-types reside within glial and neuronal cells of the cerebellum
Transplant of human chromosomes marks first step in genome synthesis project
Researchers in the LMB’s PNAC Division detail a new pipeline to implant human chromosomes into mouse cells and back again without genomic damage, marking an important step towards the overall goal of synthesising human genomes.
How is the integrated stress response terminated?
Anne Bertolotti’s group in the LMB’s Neurobiology Division has resolved a longstanding question about the termination of the ISR, a signalling pathway which is crucial for cellular homeostasis.
A new method to prepare cryo-EM samples avoids protein damage during freezing
Chris Russo’s group in the LMB’s Structural Studies Division, eliminate decades-long problem by preventing protein damage at the air–water interface with high-speed droplet vitrification.
Protein sorting in the Golgi: Should I stay or should I go?
Providing order amongst constant cargo traffic: Sean Munro’s group in the LMB’s Cell Biology Division and John Briggs’ group at the Max Planck Institute of Biochemistry, identify how GOLPH3 enables COPI vesicles to distinguish between Golgi resident and proteins bound for the endoplasmic reticulum.
Syn57 represents a new chapter in the genetic code of life
In a significant rewriting of the genome, Jason Chin’s group in the LMB’s PNAC Division have synthesised E. coli with just 57 codons, freeing seven codons which could be used to introduce non-canonical amino acids and produce novel polymers.