Anne Bertolotti’s group in the LMB’s Neurobiology Division has resolved a longstanding question about the termination of the ISR, a signalling pathway which is crucial for cellular homeostasis.
How is the integrated stress response terminated?
A new method to prepare cryo-EM samples avoids protein damage during freezing
Chris Russo’s group in the LMB’s Structural Studies Division, eliminate decades-long problem by preventing protein damage at the air–water interface with high-speed droplet vitrification.
Protein sorting in the Golgi: Should I stay or should I go?
Providing order amongst constant cargo traffic: Sean Munro’s group in the LMB’s Cell Biology Division and John Briggs’ group at the Max Planck Institute of Biochemistry, identify how GOLPH3 enables COPI vesicles to distinguish between Golgi resident and proteins bound for the endoplasmic reticulum.
Syn57 represents a new chapter in the genetic code of life
In a significant rewriting of the genome, Jason Chin’s group in the LMB’s PNAC Division have synthesised E. coli with just 57 codons, freeing seven codons which could be used to introduce non-canonical amino acids and produce novel polymers.
First structure of human telomerase in dimeric assembly
Kelly Nguyen’s group, in the LMB’s Structural Studies Division, have used cryo-EM to visualise telomerase in a dimeric formation for the first time and demonstrated how dimerization is important for telomere maintenance.
How RECQL5 applies the brakes to speeding RNA polymerase II to safeguard genome stability
Suyang Zhang’s group, in the LMB’s Structural Studies Division, has elucidated how the DNA helicase RECQL5 works with the transcription-coupled DNA repair complex to brake and accelerate RNA polymerase II transcription to maintain genome stability.