![Electron cryo-tomography of VPS34 complex II bound to Rab5 on lipid vesicles, shows a range of orientations of the complex relative to the membrane, which allows the activated VPS34 kinase to survey the vesicle for substrate.](https://www2.mrc-lmb.cam.ac.uk/wordpress/wp-content/uploads/rw_ior_3-21_complexesonvesicle-150x150.jpg)
Rare lipids in our cell membranes act as postcodes to operate regulatory processes such as autophagy and endocytosis. Roger Williams, together with Sean Munro’s and John Brigg’s groups, have shown how the G-proteins Rab1 and Rab5 activate these processes respectively, through conformational changes of kinase VPS34 complexes.