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MRC Laboratory of Molecular Biology

MRC Laboratory of Molecular Biology

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Human wound healing is affected by the body clock

Internal body clocks, which time the length of a day in almost all organisms, control many aspects of human physiology and activity, from when we go to bed to when we perform best mentally and physically. Most importantly, these biological circadian clocks are in every single individual cell of our bodies, not just in the brain.

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Published on 9th November, 2017

New insights into ubiquitin phosphorylation and the development of early-onset Parkinson’s disease

Parkinson’s disease (PD) is a neurodegenerative condition caused by the loss of dopaminergic neurons in the midbrain, which manifests clinically in the form of characteristic motor defects. Most PD cases are sporadic and found in people above the age of 60. However, roughly 10% of PD cases are autosomal recessive juvenile forms (AR-JP), causing early-onset PD.  It is known that mutations in PARK genes are responsible for this, but often a molecular explanation is lacking.

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Published on 31st October, 2017

The missing link between golgins and endosomal vesicles discovered

A model for the role of TBC1D23 as a link between the trans-Golgi network golgins and FAM21A of the WASH complex on endosome-derived vesicles.

Inside our cells there are many distinct membrane compartments – organelles – which carry out the different tasks that allow the cell to function. Each organelle is like a factory that requires a constant supply of raw materials to stay active. Small transport vesicles deliver this cargo of particular proteins and lipids to each organelle.

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Published on 30th October, 2017

How the poly(A) tail is added to the end of mRNAs

polymerase module structure

Genes are encoded in DNA and need to be copied into an intermediate mRNA molecule that contains the instructions to allow synthesis of protein. Almost every mRNA has a repetitive sequence at one end called a poly(A) tail. The length of this tail specifies the amount of time that the mRNA is present in the cell, and how often it is translated into protein. Errors or changes in the tail are found in human diseases including β-thalassemia, thrombophilia and cancer, as well as viral infections.

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Published on 27th October, 2017

Network control principles predict neuron function in the C. elegans connectome

Image of a nematode worm brain

The connectome of an animal is the comprehensive map, or wiring diagram, of all the neural connections in the brain. However, an important challenge is how to make sense of this information.  The nematode worm Caenorhabditis elegans, still the only animal for which the entire connectome has been described, illustrates the problem. Although it has only 302 neurons, these make thousands of connections.

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Published on 19th October, 2017

Folate and formaldehyde: from vitamin to genotoxin to DNA building block

Cell growth requires the synthesis of molecules, such as nucleotides to make DNA and amino acids to make proteins. One essential building block of these is the one carbon unit. This is produced by the one carbon (1C) cycle, which requires the vitamin folate and the amino acid serine (the main source of the 1C unit). 1C metabolism is important for human health, and folate deficiency causes birth defects, nerve damage and anaemia.

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Published on 17th August, 2017
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