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MRC Laboratory of Molecular Biology

MRC Laboratory of Molecular Biology

One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health.

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Home > Research > Neurobiology > Initiative with the Department of Clinical Neurosciences

Initiative with the Department of Clinical Neurosciences

The aim of this initiative is to identify core mechanisms of protein aggregation and spreading in neurodegeneration; and to apply that knowledge to first-in-human studies of putative new therapies using the most informative patients and sensitive outcome measures of efficacy.

The scientists involved from the LMB combine expertise in high-resolution structural biology, mechanisms of protein aggregation and inter-cellular transfer, and quality control processes in neurones and glia; research in the Department of Clinical Neurosciences focuses on the consequences of these events for mechanisms of neuronal and synaptic loss that lead to neurodegeneration, the development of novel therapies, and their evaluation in patients using sensitive clinical outcomes and studies of brain structure and function based on positron emission tomography and magnetic resonance imaging.

Contact Person for Neurobiology:
Michel Goedert

Contact Person for the Department of Clinical Neurosciences:
Patrick Chinnery

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