The facility’s operational model is to deliver a biology-driven facility that complements other structural and biophysical techniques. The facility offers both high-end research collaborations to answer specific biological questions and maintains the automated routine service NMR for synthetic chemistry.
Relevant advanced solution state NMR methods are implemented and can be adapted to the specific needs of LMB projects. Supported key research areas include ubiquitination and autophagy, function and dynamics of multidomain complexes and functional studies of membrane proteins.
The state-of-the-art NMR facility – located in a separate, purpose-built building – houses 500, 600, 700 and 800 MHz spectrometers, all equipped with cryoprobes and multichannel configuration. It also provides robotics for screening small molecule compound libraries against potential drug targets.
Stefan Freund is Head of the NMR facility.