Protein and Nucleic Acid Chemistry Division

The objectives of the Division are to gain insights into human biology and disease at the molecular level with a view to developing strategies for diagnosis and treatment.

Work in the Division focuses on biological processes central to immunity and cancer, and uses molecular, cellular and transgenic approaches, exploiting genomics, proteomics and molecular evolution.

In 2012 a new chemistry-oriented Centre for Chemical and Synthetic Biology (CCSB) was established, to help support the Division’s work in synthetic biology and strengthen its chemical expertise.

Group Leaders

• Mariann Bienz - Molecular mechanisms of Wnt signal transduction
• Jason Chin - Systematic genetic code reprogramming / Centre for chemical and synthetic biology
• Gerry Crossan - Maintenance of genome stability in the germline
• Philipp Holliger - Synthetic biology of nucleic acid replication
• Leo James - Intracellular immunity
• Patrycja Kozik - Dendritic cells and initiation of the immune responses
• Andrew McKenzie - Transgenic models of immune and haematopoietic disorders
• KJ Patel - Chromosome breakage and repair in stem cells
• Felix Randow - Cell-autonomous and innate immunity
• Julian Sale - Vertebrate mutagenesis and DNA damage tolerance
• John Sutherland - Chemical origins of molecular biology
• Roger Williams - Structural studies of phospholipid signalling
• Joseph Yeeles - Mechanisms of chromosome replication

Independent Investigator Scientists

• Cristina Rada - Mechanisms of Immunity in the cell nucleus

Scientific Facilities within the Division

• Biological Services
• Biophysics
• Flow Cytometry

Emeritus

• Alan Fersht - Tumour suppressor p53 structure and drug discovery
• Michael Gait - Therapeutic applications of synthetic oligonucleotide analogues & their peptide conjugates
• Greg Winter - Bicyclic peptides & chemistry of bicycles

Past Group Leaders

• Alexander Betz - Left LMB, September 2015
• David Komander - Left October 2018 to work at the Walter+Eliza Hall Institute of Medical Research

Joint Heads of Division:
Andrew McKenzie and Jason Chin

Divisional Administrator:
Michele Hare

Assistant Divisional Administrator:

Tel: +44 (0) 1223 267090
Fax: +44 (0) 1223 268306

Centre for Chemical and Synthetic Biology Administrator:
Emma Thurston Division of Protein and Nucleic Acid Chemistry,
MRC Laboratory of Molecular Biology,

Francis Crick Avenue,
Cambridge Biomedical Campus,
Cambridge CB2 0QH,
UK.

Tel: +44 (0) 1223 267089
Fax: +44 (0) 1223 268306