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MRC Laboratory of Molecular Biology

MRC Laboratory of Molecular Biology

One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health.

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Home > Research > Protein and Nucleic Acid Chemistry

Protein and Nucleic Acid Chemistry Division

The objectives of the Division are to gain insights into human biology and disease at the molecular level with a view to developing strategies for diagnosis and treatment.

Work in the Division focuses on biological processes central to immunity and cancer, and uses molecular, cellular and transgenic approaches, exploiting genomics, proteomics and molecular evolution.

In 2012 a new chemistry-oriented Centre for Chemical and Synthetic Biology (CCSB) was established, to help support the Division’s work in synthetic biology and strengthen its chemical expertise.

Group Leaders and MRC Investigators

  • Mariann Bienz - Molecular mechanisms of Wnt signal transduction
  • Jason Chin - Systematic genetic code reprogramming / Centre for Chemical and Synthetic Biology
  • Gerry Crossan - Maintenance of genome stability in the germline
  • Philipp Holliger - Evolution of novel biopolymers
  • Leo James - Host-Pathogen Biology
  • Patrycja Kozik - Dendritic cells and initiation of immune responses
  • Andrew McKenzie - Investigation of immune and haematopoietic disorders
  • Felix Randow - Cell-autonomous and innate immunity
  • Julian Sale - Vertebrate mutagenesis and DNA damage tolerance
  • John Sutherland - Chemical origins of molecular biology
  • Ana Tufegdžić Vidaković - Molecular basis of gene transcription
  • Roger Williams - Structural studies of phosphoinositide signalling and intracellular sorting
  • Joseph Yeeles - Mechanisms of chromosome replication

Scientific Facilities within the Division

  • Biological Services
  • Biophysics
  • Flow Cytometry

Emeritus

  • Alan Fersht - Tumour suppressor p53 structure and drug discovery
  • Michael Gait - Therapeutic applications of synthetic oligonucleotide analogues & their peptide conjugates
  • Greg Winter - Bicyclic peptides & chemistry of bicycles

Past Group Leaders

  • David Komander - Left October 2018 to work at the Walter+Eliza Hall Institute of Medical Research
  • KJ Patel - Left June 2020 to work at the MRC Weatherall Institute of Molecular Medicine at the University of Oxford
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Joint Heads of Division:
Andrew McKenzie and Jason Chin

Divisional Administrator:
Michele Hare

Assistant Divisional Administrator:
Bina Lathia and Aysha Islam

Tel: +44 (0) 1223 267090
Fax: +44 (0) 1223 268306

Centre for Chemical and Synthetic Biology Administrator:
Emma Thurston

Division of Protein and Nucleic Acid Chemistry,
MRC Laboratory of Molecular Biology,
Francis Crick Avenue,
Cambridge Biomedical Campus,
Cambridge CB2 0QH,
UK.

Tel: +44 (0) 1223 267089
Fax: +44 (0) 1223 268306

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Research

  • Goals and Research Focus
  • Cell Biology
  • Neurobiology
    • Initiative with the Department of Clinical Neurosciences
  • Protein and Nucleic Acid Chemistry
    • Centre for Chemical and Synthetic Biology
  • Structural Studies
  • Technology Transfer
    • History Of Technology Transfer
    • Neonatal Mouse Anaesthetisation Mould Request Form
    • Chinlab Software
    • Examples of Recent Technology Transfer Initiatives
      • Bicycle Therapeutics
      • Mesolens Microscopy
      • Gold EM Support Grids
      • In Vitro Compartmentalization (IVC)
      • CombiPuck
      • SiR (Self-inactivating Rabies virus)
      • MORPHEUS III
      • Trim-Away
      • PepGen
      • Raphin 1
      • Transgenic mice expressing human P301S tau protein (continued success since 2002)
      • Therapeutic Antibodies
  • Scientific Facilities & Support Services
    • Biological Services Group
    • Biophysics
    • Crystallisation and X-ray
    • Electron Microscopy
    • Flow Cytometry
    • Light Microscopy
    • Mass Spectrometry
    • Nanobody
    • NMR
    • Scientific Computing
    • Workshops
    • Support Services
  • Locally Developed Software
    • Image Processing Software
  • Scientific Training
    • Electron Microscopy
    • Biophysics Lectures
    • Macromolecular Crystallisation
    • Crystallography Course 2013
    • Statistics Course 2014
    • RNA-seq course 2020
  • Published Research
  • Molecular Immunity Unit
  • Animal Research
    • Why is animal research needed?
    • Alternatives to using Animals in Research
    • Welfare and ethics
    • LMB Research Involving Animals
    • LMB Animal Research Facts and Figures
    • Biological Services Group
    • Concordat on Openness in Animal Research
    • Useful Links
  • Blue Sky Collaboration
  • LMB COVID-19 response

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Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK. 01223 267000

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