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MRC Laboratory of Molecular Biology

MRC Laboratory of Molecular Biology

One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health.

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Home > Research > Scientific Facilities & Support Services > NMR

NMR

NMR panorama

NMR spectroscopy is a powerful method for resolving the structure, dynamics and interactions of proteins and nucleic acids in solution.

Located in a separate, purpose-built building, our state-of-the-art NMR facility houses 500, 600, 700, and 800 MHz spectrometers all equipped with cryoprobes for improved sensitivity, as well as currently hosting an AstraZeneca spectrometer and two of their NMR spectroscopists.

The goal of the LMB NMR facility is to offer high-quality, collaborative research as part of an integrated structural biology approach within the LMB, bridging the gap between biophysical measurements and structure determination. Facility staff draw on their diverse scientific experience, enabling unique insight into experimental design, sample preparation, data collection and analysis. The most recent work within the facility has focused on autophagy, ubiquitination, phosphorylation, signalling pathway regulation and the interactions of proteins with low structural complexity.

The facility staff also maintain two automated 400 MHz spectrometers used by synthetic chemists at the LMB.

Stefan Freund is Head of the NMR facility.

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Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK. 01223 267000

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