MRC Laboratory of Molecular Biology
One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health.
New research from Madan Babu’s group in the LMB’s Structural Studies Division, in collaboration with Toby Gibson from the European Molecular Biology Laboratory in Heidelberg, has shown that the targeted movement of mRNA molecules to allow proteins to be synthesised in specific locations has important implications in cell signalling and development.
Whilst a mother’s metabolism provides essential nutrients to enable embryonic development, both mother and embryo can also produce reactive metabolites that can damage DNA. Research undertaken by Nina Oberbeck in KJ Patel’s group, in the LMB’s PNAC Division, has uncovered how the embryo is protected from these genotoxins.
Birth defects are common and are a substantial burden to human health, but their causes are complex and often due to many factors.
Research carried out by Anne Bertolotti’s group in the LMB’s Neurobiology Division has identified a novel protein, named Adc17, that acts as an inducible chaperone to help cells make more proteasome when needed.
Cells and organisms constantly need to adapt to maintain protein homeostasis under adverse stress conditions in order to avoid cell death. Cells have evolved numerous and sophisticated protein quality control systems to adapt to changes in their environment.
The latest advances in cryo-electron microscopy have enabled Sjors Scheres’ group, from the LMB’s Structural Studies Division, together with collaborators from Beijing in China, to solve the structure of human gamma-secretase, a membrane protein complex that has an important role in Alzheimer’s disease.
Gamma-secretase is made up of four different proteins which are all embedded within the cell membrane.
A cross divisional collaboration at the LMB between the groups of Simon Bullock, in Cell Biology, and Andrew Carter, in Structural Studies, has provided new insight into the activation of the large molecular motor dynein, a critical component of the transport system that operates within cells.
The cells within living organisms contain an elaborate transport system that moves different components to the right part of the cell at the right time.
A collaborative team from LMB’s Cell Biology and Structural Studies Divisions has visualized the mammalian protein synthesis and export machinery at near-atomic resolution. The new research helps explain how secreted proteins, such as hormones, can cross an otherwise impermeable membrane to exit the cell.
It has long been appreciated that cells communicate with each other via proteins that are either secreted or embedded in the cell’s surface.